gene 1,850 words KG: DGUOK 2026-03-26
kind:genesection:genesstate:published
Contents

DGUOK — Deoxyguanosine Kinase

🧬 Gene Info
Gene SymbolDGUOK
Full NameDeoxyguanosine Kinase
Chromosome2p13.1
Protein FamilyDeoxyguanosine kinase family
Protein TypeEnzyme
Functionis a nuclear-encoded gene that encodes a crucial mitochondrial enzyme involved in the nucleotide salvage pathway.
Primary Expressionall human tissues with particularly high expression in liver, kidney, and brain
Subcellular Localizationthe mitochondrial matrix. Each subunit contains an N-terminal mitochondrial targeting peptide (approximately 30 amino ac
Molecular Weight34 kDa
Amino Acids278 aa
Exons7
UniProt ID[Q01459](https://www.uniprot.org/uniprot/Q01459)
Ensembl IDENSG00000198246
OMIM601465
GeneCardsDGUOK
Human Protein AtlasDGUOK
Associated Diseasesneurodegeneration
KG Connections33 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

PARP1 Inhibition Therapy
Score: 0.58
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (2)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: expressed_in
TYMP Gene
gene · KG edge: associated_with
TK2 Gene
gene · KG edge: associated_with
TFAM Gene
gene · KG edge: associated_with
SUCLG1 — Succinate-CoA Ligase GDP Forming Subunit Alpha
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DGUOK associated_with SUCLG1
DGUOK associated_with TK2
DGUOK associated_with TYMP
DGUOK contributes_to MPV17
DGUOK associated_with SUCLA2
DGUOK associated_with RRM2B
DGUOK contributes_to POLG
DGUOK associated_with GENES
DGUOK associated_with DNA
DGUOK expressed_in Als