gene 2,080 words KG: SUCLA2 2026-03-27
kind:genesection:genesstate:published
Contents

SUCLA2 Gene

🧬 Gene Info
Gene SymbolSUCLA2
Full NameSuccinate-CoA Ligase ADP Forming Subunit Beta
AliasesSCS-β, SUCL-BETA, Beta-succinyl CoA synthetase
Chromosome13q14.2
Protein TypeEnzyme
Functionencodes the β subunit of ADP-forming succinyl-CoA synthetase (SCS), also known as succinate-CoA ligase ADP-forming GDP form
Primary Expressiontissues with high ATP demand, including brain, heart, and skeletal muscle
Molecular Weight35 kDa
Amino Acids30 aa
UniProt IDP53999
NCBI Gene ID8802
Ensembl IDENSG00000147576
OMIM603921
GeneCardsSUCLA2
Human Protein AtlasSUCLA2
Associated Diseasesneurodegeneration
KG Connections29 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.38
CYP46A1 Overexpression Gene Therapy
Score: 0.63
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.47
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.38

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Packard Center for ALS Research
institution · KG edge: expressed_in
TWNK Gene
gene · KG edge: associated_with
TFAM Gene
gene · KG edge: associated_with
SUCLG1 — Succinate-CoA Ligase GDP Forming Subunit Alpha
gene · KG edge: associated_with
SLC25A4 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

SUCLA2 associated_with SUCLG1
SUCLA2 associated_with TFAM
SUCLA2 associated_with POLG
SUCLA2 associated_with RNASEH1
SUCLA2 associated_with OPA1
SUCLA2 associated_with TWNK
SUCLA2 associated_with MPV17
SUCLA2 associated_with DGUOK
SUCLA2 expressed_in RRM2B
SUCLA2 associated_with DNA