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mechanism 1,833 words KG: stress
Contents

stress-granule-disease-comparison

⚙ Mechanism Info
Namestress
Key Genes/ProteinsERK, MMP9
Related Diseasesdepression, neurodegeneration, pulse rate, senescence
Related PathwaysLRRK2 G2019S pathogenic signaling, microbiota-gut-brain axis, mitochondrial_dysfunction, neuroinflammation
Linked Hypotheses31 hypotheses

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Related Hypotheses (16)

eIF2α Phosphorylation Imbalance Creates Integrated Stress Re
Score: 0.90ATM Kinase Hyperactivation Triggers DNA Damage Response Over
Score: 0.84TIA1 Low-Complexity Domain Oxidation Drives Aberrant Stress
Score: 0.81GRN/progranulin lysosomal insufficiency across FTD, ALS-spec
Score: 0.76A downstream LRRK2-Rab10-JIP4 lysosomal stress loop promotes
Score: 0.68Rab12 may better report chronic lysosomal stress biology tha
Score: 0.67Amyloid-beta induces secondary pericyte senescence after con
Score: 0.64mutant FUS effects split between motor-neuron intrinsic stre
Score: 0.63ATF4-DDIT3 stress signaling indirectly represses MAPT transc
Score: 0.62A genetically encoded reporter for axonal mitochondrial prot
Score: 0.57BBB leak induces secondary pericyte senescence through TGF-b
Score: 0.56SIRT3 loss creates a mitochondrial acetylation-stress loop t
Score: 0.56REST-like neuronal silencing programs suppress MAPT in sever
Score: 0.51Reactive astrocyte glutamate-handling failure sustains dendr
Score: 0.49Astrocyte-specific autophagy deficiency induces NADPH oxidas
Score: 0.39XOR+ stress-responsive astrocytes represent a novel AD-assoc
Score: 0.38

Knowledge Graph (12 edges)

locus coeruleus regulates stress
stress activates MMP9
stress modulates microbiota-gut-brain axis
stress risk_factor_for depression
stress associated_with pulse rate
32250301 are not mediated by stress
stress triggers senescence
stress activates ERK
neuroinflammation associated_with stress
stress increases_risk mitochondrial_dysfunction

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