therapeutic 1,046 words KG: ent-gene-cd5fb780
Contents

PGC-1α (PPARGC1A) Targeted Therapies in Neurodegeneration

🔬 Protein Info
Gene SymbolPGC
Full Name1α (PPARGC1A) Targeted Therapies in Neurodegeneration
Chromosome4p15.1
FunctionPgc 1Α Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCardsPGC
Human Protein AtlasPGC
GenePPARGC1A (PPAR gamma coactivator 1 alpha)
LocationChromosome 4p15.1
Protein size798 amino acids
Key domainsTransactivation domain, RS domain, RNA recognition motif
CoregulatorActivates nuclear receptors and transcription factors
NRF-1/2Nuclear respiratory factors
TFAMMitochondrial transcription factor A
ERRαEstrogen-related receptor alpha
PPARsPeroxisome proliferator-activated receptors
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.88
SASP-Mediated Complement Cascade Amplification
Score: 0.87
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.86
CYP46A1 Overexpression Gene Therapy
Score: 0.86
Transcriptional Autophagy-Lysosome Coupling
Score: 0.84

Related Analyses (30)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · completed
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · completed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (30)

GWAS meta-analysis of major depressive disorder across three
exploratory · proposed · Score: 0.95
Differential GWAS of schizophrenia vs PTSD
exploratory · proposed · Score: 0.90
PGC-1α knockout effects on PV+ interneuron maturation
validation · proposed · Score: 0.90
TUG C-terminal product nuclear localization and PPARγ bindin
exploratory · proposed · Score: 0.85
TUG C-terminal fragment nuclear interactions
exploratory · proposed · Score: 0.85

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypotheses
China Neurodegeneration Epidemiology
disease · Pages share 139 hypotheses
Neuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypotheses
Synaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypotheses
Olfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (2 edges)

ent-gene-cd5fb780 data_in benchmark_ot_ad_answer_key:PPARGC1A
benchmark_ot_ad_answer_key:PPARGC1A data_in ent-gene-cd5fb780

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