| Gene Symbol | UBE2N |
| Full Name | Ubiquitin-Conjugating Enzyme E2 N |
| Chromosome | 19q13.43 |
| Protein Type | Enzyme |
| Function | Initiation: UBE2N~Ub thioester forms via ATP-dependent charging |
| Molecular Weight | 17 kDa |
| Pathways | NF-κB, NF-κB Signaling |
| UniProt ID | [P61079](https://www.uniprot.org/uniprot/P61079) |
| Ensembl ID | ENSG00000108987 |
| OMIM | 607252 |
| GeneCards | UBE2N |
| Human Protein Atlas | UBE2N |
| NF-κB Signaling | Lys63-polyubiquitin chains on TRAF6, NEMO, and other signaling intermediates activate NF-κB transcription factors[@adhikari2007] |
| DNA Damage Repair | UBE2N-mediated ubiquitination promotes recruitment of repair factors to DNA double-strand breaks[@hofmann2009] |
| Endosomal Trafficking | Ubiquitination of membrane proteins regulates sorting into multivesicular bodies |
| Associated Diseases | ALS |
| Interactions | Actin, CANCER, CDK1, CRBN, DNAJB6, FERROPTOSIS |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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