gene 1,478 words KG: CDK1 2026-03-27
kind:genesection:genesstate:published
Contents

CDK1 — Cyclin-Dependent Kinase 1

🧬 Gene Info
Gene SymbolCDK1
Full NameCyclin-Dependent Kinase 1
Chromosome10q21.1
Protein TypeKinase
Functionis a gene located on chromosome 10q21.
Primary ExpressionUbiquitous (neurons, glia, proliferating cells)
Molecular Weight34 kDa
Amino Acids297 aa
PathwaysAngiogenesis, Autophagy, Cell Cycle, Differentiation, Epigenetic
UniProt IDP06493
NCBI Gene ID983
Ensembl IDENSG00000164946
OMIM176741
GeneCardsCDK1
Human Protein AtlasCDK1
Associated DiseasesALS, Cancer, Inflammation
Known Drugs/Compoundsrapamycin
InteractionsBECN1, APP, TAU, CDK5, CDK2, PIEZO1
KG Connections340 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (15)

Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.48
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.39
Noradrenergic-Tau Propagation Blockade
Score: 0.51
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

See Also (12)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: therapeutic_target
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
BAX Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CDK1 regulates ARNT
CDK1 regulates CLOCK
CDK1 therapeutic_target BRAF
CDK1 inhibits BECN1
CDK1 inhibits APP
CDK1 inhibits TAU
CDK1 activates CDK5
CDK1 expressed_in EGFR
CDK1 expressed_in H2AX
CDK1 expressed_in GBM