CRBN

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRBN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    CRBN["CRBN"]
    CRBN -->|"regulates"| protein_degradation["protein degradation"]
    CRBN -->|"ubiquitinates"| IKZF1["IKZF1"]
    CRBN -->|"ubiquitinates"| IKZF3["IKZF3"]
    CRBN -->|"interacts"| UBIQUITIN["UBIQUITIN"]
    CRBN -->|"target for"| Cancer["Cancer"]
    CRBN -->|"target for"| Als["Als"]
    CRBN -->|"activates"| Senescence["Senescence"]
    thalidomide_analogs["thalidomide analogs"] -->|"binds_to"| CRBN
    CRL4["CRL4"] -->|"component_of"| CRBN
    AND["AND"] -->|"activates"| CRBN
    CDK4["CDK4"] -->|"activates"| CRBN
    RB1["RB1"] -->|"inhibits"| CRBN
    UBIQUITIN -->|"interacts"| CRBN
    DNAJB6["DNAJB6"] -->|"interacts"| CRBN
    RNA["RNA"] -->|"interacts"| CRBN