| Gene Symbol | VAMP2 |
| Aliases | Page for VAMP2 Gene, Synaptobrevin-2 |
| Chromosome | 17p13.1 |
| Protein Type | Protein |
| Function | Vesicle Docking: VAMP2 on vesicles pairs with syntaxin-1A on plasma membrane |
| Molecular Weight | 12.6 kDa |
| Amino Acids | 116 aa |
| Exons | 5 |
| UniProt ID | P60880 |
| GeneCards | VAMP2 |
| Human Protein Atlas | VAMP2 |
| N-terminal region (residues 1-28) | A proline-rich, highly flexible segment that lacks secondary structure. This region contains the site for phosphorylation by casein kinase 2, which modulates VAMP2 function. |
| SNARE motif (residues 29-60) | The central region that forms the core of the SNARE complex. This alpha-helical segment undergoes conformational changes during SNARE assembly. |
| Transmembrane domain (residues 76-94) | A single-pass transmembrane anchor that tethers VAMP2 to synaptic vesicles. This region consists of a helical transmembrane segment near the C-terminus. |
| C-terminal region (residues 95-116) | The extreme C-terminus contributes to membrane association and may participate in interactions with other SNARE proteins. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | AGING, ALPHA-SYNUCLEIN, AMYLOID, AND, APOE, APOE3 |
| KG Connections | 79 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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