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G3BP1-mediated stress granule assembly via liquid-liquid phase separation

experiment Created: 2026-04-04 05:25:48 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-3cba09b1-8b1b-427c-8c4e-9
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G3BP1
Metadata
experiment_typecell_biology
protocolAnalysis of protein-RNA interaction networks, examination of intrinsically disordered regions, phosphorylation studies, and investigation of G3BP1-binding factor cooperativity
expected_outcomesG3BP1 acts as a tunable switch for stress granule assembly through RNA-dependent liquid-liquid phase separation
success_criteriademonstration of G3BP1's role as molecular switch and identification of regulatory mechanisms
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-03T22:25:41.559723
source_pmid32302571
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-04T05:25:41.562665'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (140)
derives_from📄G3BP1 Is a Tunable Switch that Triggers Phase Separation to 100%
experiment_target📖G3BP1100%
mentions📖G3BP1100%
mentions📖G3BP1 Protein — Ras-GTPase-Activating Protein-Binding Protei80%
related📖G3BP1 Protein — Ras-GTPase-Activating Protein-Binding Protei72%
mentions📖G3BP170%
mentions📖LLPS Modulator Therapy70%
mentions📖RNA Binding Fox-1 Homolog 1 (RBFOX1)70%
mentions📖RNA Binding Fox-1 Homolog 2 (RBFOX2)70%
mentions📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)70%
mentions📖RNA Therapeutics: Investment Landscape Analysis70%
mentions📖RNA Therapeutics for Neurodegeneration Investment Landscape70%
mentions📖RNA Metabolism Dysfunction in Corticobasal Syndrome70%
mentions📖RNA Metabolism Dysregulation in Alzheimer's Disease70%
mentions📖RNA G-quadruplexes in Neurodegeneration70%
mentions📖RNA Granule Dysfunction in Neurodegeneration70%
mentions📖RNA Metabolism in Neurodegeneration70%
mentions📖RNA Metabolism Dysregulation in 4R-Tauopathies70%
mentions📖RNA Metabolism in Alzheimer's Disease70%
mentions📖RNA Metabolism Dysregulation Pathway70%
mentions📖RNA Processing in Neurodegeneration70%
mentions📖RNA Splicing in Neurodegeneration70%
mentions📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 70%
mentions📖RNA Splicing Defects in Neurodegeneration70%
mentions📖RNA Stability and Decay70%
mentions📖RNA-Targeted Therapies in Neurodegeneration70%
mentions📖RNA-Targeted Therapeutics Investment Synthesis70%
mentions📖RNA Toxicity Pathway70%
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related📖G3BP163%
related📖LLPS Modulator Therapy63%
related📖RNA Binding Fox-1 Homolog 1 (RBFOX1)63%
related📖RNA Binding Fox-1 Homolog 2 (RBFOX2)63%
related📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)63%
related📖RNA Therapeutics: Investment Landscape Analysis63%
related📖RNA Therapeutics for Neurodegeneration Investment Landscape63%
related📖RNA Metabolism Dysfunction in Corticobasal Syndrome63%
related📖RNA Metabolism Dysregulation in Alzheimer's Disease63%
related📖RNA G-quadruplexes in Neurodegeneration63%
related📖RNA Granule Dysfunction in Neurodegeneration63%
related📖RNA Metabolism in Neurodegeneration63%
related📖RNA Metabolism Dysregulation in 4R-Tauopathies63%
related📖RNA Metabolism in Alzheimer's Disease63%
related📖RNA Metabolism Dysregulation Pathway63%
related📖RNA Processing in Neurodegeneration63%
related📖RNA Splicing in Neurodegeneration63%
related📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 63%
related📖RNA Splicing Defects in Neurodegeneration63%
related📖RNA Stability and Decay63%
related📖RNA-Targeted Therapies in Neurodegeneration63%
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related📖RNA Toxicity Pathway63%
related📖RNA Editing Therapeutics63%
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related📖RNA Targeting Therapy for Neurodegeneration63%
related📖RNA-Based Therapeutics for Neurodegenerative Diseases63%
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mentions📖Liquid-Liquid Phase Separation60%
mentions📖mechanisms60%
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related🧫G3BP1-binding factor cooperativity in stress granule network60%
related🧫TRIM21-mediated K63-linked ubiquitination of G3BP160%
related🧫G3BP1 intrinsically disordered region analysis and phosphory60%
related🧪Liquid-Liquid Phase Separation Modifier Therapy60%
related🧪Stress Granule Phase Separation Modulators60%
related🧪Phase-Separated Organelle Targeting60%
related🧪RNA Granule Nucleation Site Modulation60%
related📖Liquid-Liquid Phase Separation54%
related📖mechanisms54%
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mentions📖PSP Liquid-Liquid Phase Separation and Biomolecular Condensa50%
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mentions📖C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chai50%
mentions📖Ferroptosis in Neurodegeneration50%
mentions📖Oxidative Stress in Neurodegeneration50%
mentions📖Protein Phase Separation in Parkinson's Disease50%
mentions📖Stress Granule Homeostasis in ALS/FTD50%
mentions📖Stress Granules and RNP Granules50%
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mentions📖Frontal Cortex Layer 2 Neurons in Frontotemporal Dementia50%
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mentions📖Stress Granule Formation in Neurodegeneration50%
mentions📖biomolecular-condensates-4r-tauopathies50%
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mentions📖Stress Granules in Neurodegeneration50%
mentions📖Stress Granule Dynamics in Neurodegeneration50%
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💬 Discussion