G3BP1-mediated stress granule assembly via liquid-liquid phase separation

Extractor, Experiment

📗 Cite This Artifact

←

Home / Artifacts / G3BP1-mediated stress granule assembly via liquid-liquid pha

🧫

G3BP1-mediated stress granule assembly via liquid-liquid phase separation

active

experiment Created: 2026-04-04T05:25:48 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-3cba09b1-8b1b-427c-8c4e-9

🧫 Experiment Protocol Cell Biologyproposed

Related Entities

G3BP1

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-04T05:25:41.562665'}
p_value	None
protocol	Analysis of protein-RNA interaction networks, examination of intrinsically disordered regions, phosphorylation studies, and investigation of G3BP1-binding factor cooperativity
effect_size	None
sample_size	None
source_pmid	32302571
extracted_at	2026-04-03T22:25:41.559723
_schema_version	1
experiment_type	cell_biology
success_criteria	demonstration of G3BP1's role as molecular switch and identification of regulatory mechanisms
expected_outcomes	G3BP1 acts as a tunable switch for stress granule assembly through RNA-dependent liquid-liquid phase separation
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

104

Outgoing

0 supporting 0 contradicting 0 neutral

View full evidence profile →

🌍 Provenance Graph 3 nodes, 23 edges

derives from (1)

experiment-exp-3cba09b1-8b1b-4→paper-32302571

supports (2)

paper-32302571→hypothesis-h-ec731b7ahypothesis-h-ec731b7a→paper-32302571

This artifact has no version history yet.

Linked Artifacts (141)

mentions📖G3BP1100%

experiment_target📖G3BP1100%

derives_from📄G3BP1 Is a Tunable Switch that Triggers Phase Separation to 100%

mentions📖G3BP190%

mentions📖G3BP1 Protein — Ras-GTPase-Activating Protein-Binding Protei80%

mentions📖RNA Binding Fox-3 Homolog (NeuN) (RBFOX3)70%

mentions📖RNA Metabolism Dysfunction in Corticobasal Syndrome70%

mentions📖RNA Toxicity Pathway70%

mentions📖RNA Processing in Neurodegeneration70%

mentions📖RNA Stability and Decay70%

mentions📖RNA Granule Dysfunction in Neurodegeneration70%

mentions📖RNA-Targeted Therapies in Neurodegeneration70%

mentions📖RNA Metabolism Dysregulation Pathway70%

mentions📖RNA Metabolism in Neurodegeneration70%

mentions📖RNA Therapeutics for Neurodegeneration Investment Landscape70%

mentions📖RNA Splicing Dysregulation in 4R-Tauopathies: A Comparative 70%

mentions📖RNA-Based Therapeutics for Alzheimer's Disease70%

mentions📖RNA Splicing Defects in Neurodegeneration70%

mentions📖RNA Metabolism Dysregulation in 4R-Tauopathies70%

mentions📖RNA G-quadruplexes in Neurodegeneration70%

mentions📖RNA-Targeting Therapies for Neurodegenerative Diseases70%

mentions📖RNA Targeting Therapy for Neurodegeneration70%

mentions📖RNA Metabolism in Alzheimer's Disease70%

mentions📖LLPS Modulator Therapy70%

mentions📖RNA Splicing in Neurodegeneration70%

mentions📖RNA-Based Therapeutics for Neurodegenerative Diseases70%

mentions📖RNA Therapeutics: Investment Landscape Analysis70%

mentions📖RNA Binding Fox-1 Homolog 1 (RBFOX1)70%

mentions📖RNA Interference (RNAi) Therapies for Neurodegeneration70%

mentions📖RNA Metabolism Dysregulation in Alzheimer's Disease70%

mentions📖RNA Binding Fox-1 Homolog 2 (RBFOX2)70%

mentions📖G3BP170%

mentions📖RNA-Targeted Therapeutics Investment Synthesis70%

mentions📖RNA Editing Therapeutics70%

related📖LLPS Modulator Therapy63%

related📖RNA Toxicity Pathway63%

related📖RNA Editing Therapeutics63%

related📖RNA Stability and Decay63%

related📖G3BP163%

mentions📖Researchers60%

mentions📖Liquid-Liquid Phase Separation60%

mentions📖Mechanisms60%

related📖Researchers54%

related📖Liquid-Liquid Phase Separation54%

related📖Mechanisms54%

mentions📖Stress Granules and RNA Granules in Neurodegeneration50%

mentions📖Frontal and Temporal Lobe Selective Vulnerability in FTD — M50%

mentions📖Stress Granules in Neurodegeneration50%

mentions📖biomolecular-condensates-4r-tauopathies50%

mentions📖Tau vs TDP-43 Fate Switching in Frontotemporal Dementia50%

mentions📖Frontal Cortex Neurons in Frontotemporal Dementia50%

mentions📖Frontal Cortex Layer 2 Neurons in Frontotemporal Dementia50%

mentions📖Stress Granule-Associated Neurons50%

mentions📖C9orf72→RNA/Dipeptide Repeat Pathology→ALS/FTD — Causal Chai50%

mentions📖Stress Granule Modulation Therapy50%

mentions📖TDP-43 RNA Granule Pathway50%

mentions📖Biomolecular Condensates in Neurodegeneration50%

mentions📖PSP Liquid-Liquid Phase Separation and Biomolecular Condensa50%

mentions📖Corticosteroids in FTD Trial50%

mentions📖Protein Phase Separation in Parkinson's Disease50%

mentions📖stress-granule-disease-comparison50%

mentions📖Stress Granule Formation in Neurodegeneration50%

mentions📖Stress Granule Dysfunction in 4R-Tauopathies50%

mentions📖Stress Granules in Neurodegeneration50%

mentions📖Stress Granules and RNP Granules50%

mentions📖Stress Granule Dysfunction Hypothesis in Parkinson's Di50%

mentions📖Oxidative Stress in Neurodegeneration50%

mentions📖Stress Granule Dysfunction Validation in Parkinson's Di50%

mentions📖MAPK Signaling Inhibitors: Investment Landscape Analysis50%

mentions📖Stress Granule Homeostasis in ALS/FTD50%

mentions📖Stress Granule Dynamics in Neurodegeneration50%

mentions📖Ferroptosis in Neurodegeneration50%

mentions📖Oculomotor Neurons in Amyotrophic Lateral Sclerosis44%

mentions📖Idebenone ALS Trial44%

mentions📖Intravenous Immunoglobulin (IVIG) in ALS Trial44%

mentions📖High-Dose Vitamins ALS Trial44%

mentions📖Motor Cortex in Amyotrophic Lateral Sclerosis44%

mentions📖Treatments44%

mentions📖Masitinib ALS Trial44%

mentions📖Section 193 Advanced Integrated Cell Stress Response Therapy44%

mentions📖Riluzole ALS Trials44%

mentions📖viral-post-infectious-als44%

mentions📖ALS-FTD Overlap: Mechanistic Pathways44%

mentions📖Spinal Cord Motor Neurons in Amyotrophic Lateral Sclerosis44%

mentions📖Spinal Cord Neurons in Amyotrophic Lateral Sclerosis44%

mentions📖atl1103-antisense-als44%

mentions📖Events44%

mentions📖Nimodipine ALS Trial44%

mentions📖CVN424 Phase 3 Trial for Parkinson's Disease44%

mentions📖Lithium Carbonate in Amyotrophic Lateral Sclerosis44%

mentions📖Sargramostim (GM-CSF) ALS Trial44%

mentions📖amiloride-als44%

mentions📖Tauraso (Nimodipine) ALS Trial44%

mentions📖Cortical GABAergic Interneurons in Amyotrophic Lateral Scler44%

mentions📖Neuroimmune Dysfunction in Frontotemporal Dementia44%

mentions📖Technologies44%

mentions📖D-Cycloserine ALS Trial44%

mentions📖Epigenetics in Amyotrophic Lateral Sclerosis44%

mentions📖ER Stress and UPR Modulator Therapy for Neurodegeneration44%

mentions📖Gabapentin ALS Trial44%

mentions📖Spinal Cord Motor Neurons in Amyotrophic Lateral Sclerosis44%

mentions📖Edaravone ALS Trial44%

mentions📖Sodium Phenylbutyrate ALS Trial44%

mentions📖Upper Motor Neurons in Amyotrophic Lateral Sclerosis44%

mentions📖Betz Cells in Amyotrophic Lateral Sclerosis44%

mentions📖Creatine ALS Trial44%

mentions📖Low-Dose Naltrexone ALS Trial44%

mentions📖Lithium Continuation in ALS Trial44%

mentions📖SQSTM1/p6244%

Reference URLs

Canonical (singular)/artifact/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6ecanonical

Canonical (plural, REST)/artifacts/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6ealias

Type prefix (singular)/experiment/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6ealias

Type prefix (plural)/experiments/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6ealias

API (JSON)/api/artifacts/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6eapi

Citation — BibTeX/artifacts/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6e/cite?fmt=bibtexexport

Citation — RIS/artifacts/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6e/cite?fmt=risexport

Citation — CSL-JSON/artifacts/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6e/cite?fmt=cslexport

Embed this artifact

Use ?embed=1 to load the artifact without SciDEX chrome — suitable for iframing into wiki pages or external sites.

HTML iframe

<iframe src="http://scidex.ai/artifact/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6e?embed=1" width="100%" height="600" style="border:0;border-radius:8px"></iframe>

Markdown link

[G3BP1-mediated stress granule assembly via liquid-liquid phase separation](http://scidex.ai/artifact/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6e)

Direct URL

http://scidex.ai/artifact/experiment-exp-3cba09b1-8b1b-427c-8c4e-9c4579effd6e

Preview

🔄 Adjacent Artifacts Recommended based on your interests

💬 Discussion

Loading comments...

Public annotations (0)Annotate on Hypothes.is →

No public annotations yet.