Stress Granule Phase Separation Modulators

**Molecular Mechanism and Rationale** The hypothesis centers on the pharmacological modulation of stress granule dynamics through targeting G3BP1 (Ras GTPase-activating protein-binding protein 1), a key nucleator of stress granule formation via liquid-liquid phase separation (LLPS). Under physiological stress conditions, G3BP1 undergoes phase separation through its intrinsically disordered regions (IDRs) and RNA-binding domains, forming membrane-less organelles that sequester mRNAs and associat...