Liquid-Liquid Phase Separation Modifier Therapy

Liquid-Liquid Phase Separation (LLPS) Modifier Therapy targets the biophysical process by which intrinsically disordered proteins demix from the cytoplasm to form membraneless organelles — biomolecular condensates — that serve as hotspots for pathological protein co-aggregation and cross-seeding in neurodegenerative diseases. By modulating the material properties, composition, and dynamics of these condensates with small molecules, this approach aims to prevent the aberrant mixing of tau, α-synu...