Liquid-Liquid Phase Separation Modifier Therapy

graph TD
    A["Cellular Stress Triggers"]
    B["G3BP1 Activation"]
    C["Stress Granule Formation"]
    D["LLPS Nucleation"]
    E["Tau/alpha-synuclein/TDP-43 Recruitment"]
    F["Aberrant Protein Co-aggregation"]
    G["Cross-seeding Events"]
    H["Pathological Condensate Maturation"]
    I["Neuronal Dysfunction"]
    J["Synaptic Loss"]
    K["Neurodegeneration"]
    L["LLPS Modifier Compounds"]
    M["Condensate Property Modulation"]
    N["Restored Protein Dynamics"]
    O["Neuroprotective Outcome"]
    P["FUS/hnRNPA1 Co-factors"]

    A -->|"oxidative/proteotoxic"| B
    B -->|"RNA binding"| C
    C -->|"phase transition"| D
    D -->|"aberrant recruitment"| E
    P -->|"co-assembly"| E
    E -->|"pathological mixing"| F
    F -->|"prion-like propagation"| G
    G -->|"condensate aging"| H
    H -->|"cellular toxicity"| I
    I -->|"connectivity loss"| J
    J -->|"progressive damage"| K
    L -->|"therapeutic intervention"| M
    M -->|"restored fluidity"| N
    N -->|"prevention of aggregation"| E
    N -->|"neuroprotection"| O

    classDef mechanism fill:#4fc3f7,color:#0d0d1a
    classDef pathology fill:#ef5350,color:#0d0d1a
    classDef therapy fill:#81c784,color:#0d0d1a
    classDef outcome fill:#ffd54f,color:#0d0d1a
    classDef genetics fill:#ce93d8,color:#0d0d1a

    class A,D,E,F mechanism
    class G,H,I,J,K pathology
    class L,M,N therapy
    class O outcome
    class B,C,P genetics