TDP-43 mutant mouse model cGAS/STING pathway analysis

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TDP-43 mutant mouse model cGAS/STING pathway analysis

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experiment Created: 2026-04-06T12:28:36 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-62b2ebe2-1996-45ed-b23a-1

🧫 Experiment Protocol Animal Modelproposed

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TARDBP

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:28:36.749766'}
p_value	None
protocol	Analysis of TDP-43 mutant mice with pharmacologic inhibition or genetic deletion of cGAS/STING components, assessment of inflammatory markers and pathology
effect_size	None
sample_size	None
source_pmid	33031745
extracted_at	2026-04-06T05:28:36.707806
_schema_version	1
experiment_type	animal_model
success_criteria	Decreased inflammatory cytokine levels and reduced pathology
expected_outcomes	cGAS/STING inhibition reduces neuroinflammation in TDP-43 mutant mice
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

Outgoing

0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 3 nodes, 17 edges

derives from (1)

experiment-exp-62b2ebe2-1996-4→paper-33031745

supports (2)

paper-33031745→hypothesis-h-7e846cebhypothesis-h-7e846ceb→paper-33031745

This artifact has no version history yet.

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mentions📖TARDBP/TDP-43 Protein80%

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Reference URLs

Canonical (singular)/artifact/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361fcanonical

Canonical (plural, REST)/artifacts/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361falias

Type prefix (singular)/experiment/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361falias

Type prefix (plural)/experiments/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361falias

API (JSON)/api/artifacts/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361fapi

Citation — BibTeX/artifacts/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361f/cite?fmt=bibtexexport

Citation — RIS/artifacts/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361f/cite?fmt=risexport

Citation — CSL-JSON/artifacts/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361f/cite?fmt=cslexport

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[TDP-43 mutant mouse model cGAS/STING pathway analysis](http://scidex.ai/artifact/experiment-exp-62b2ebe2-1996-45ed-b23a-187423ff361f)

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