TDP-43 mitochondrial invasion and DNA release via mPTP

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TDP-43 mitochondrial invasion and DNA release via mPTP

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experiment Created: 2026-04-06T12:28:36 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-8575c9eb-9a3a-4d9a-9a26-e

🧫 Experiment Protocol Cell Biologyproposed

Related Entities

TARDBP

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:28:36.710159'}
p_value	None
protocol	Assessment of TDP-43 localization to mitochondria, measurement of mitochondrial permeability transition pore opening, and detection of cytoplasmic mtDNA release
effect_size	None
sample_size	None
source_pmid	33031745
extracted_at	2026-04-06T05:28:36.707796
_schema_version	1
experiment_type	cell_biology
success_criteria	Detection of mtDNA in cytoplasm following TDP-43 mitochondrial invasion
expected_outcomes	TDP-43 invasion of mitochondria triggers mPTP opening and subsequent mtDNA release
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

Outgoing

0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 3 nodes, 17 edges

derives from (1)

experiment-exp-8575c9eb-9a3a-4→paper-33031745

supports (2)

paper-33031745→hypothesis-h-7e846cebhypothesis-h-7e846ceb→paper-33031745

This artifact has no version history yet.

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mentions📖TARDBP — TAR DNA Binding Protein 4380%

mentions📖TARDBP Protein (TDP-43)80%

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related📖TARDBP/TDP-43 Protein72%

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mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%

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mentions📖DNA Sensing Pathways in Neurodegeneration70%

mentions📖DNA Damage and Repair in Neurons70%

mentions📖DNA Methylation Biomarkers in Neurodegeneration70%

mentions📖DNA Damage Response in Corticobasal Syndrome70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%

mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%

mentions📖DNA Damage Response in Neurodegeneration70%

mentions📖DNA Repair Therapy for Neurodegeneration70%

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mentions📖DNA Damage Repair Therapy for Neurodegeneration70%

mentions📖DNA Damage Repair Investment Landscape70%

mentions📖tdp-43-fus-rna-proteinopathy-comparison70%

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mentions📖DNA Damage Response in Alzheimer's Disease70%

mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%

mentions📖TDP-43 Proteinopathy in ALS70%

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mentions📖DNA Damage Response in Alzheimer's Disease70%

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mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%

mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%

mentions📖TDP-43 Protein70%

mentions📖DNA Damage Response in 4R-Tauopathies70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖DNA Damage Response in Corticobasal Syndrome70%

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mentions📖DNA Damage Response in Neurons70%

mentions📖TDP-43 Proteinopathy70%

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mentions📖DNA Damage Response in Parkinson's Disease70%

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related📖DNA Ligase III Protein63%

related📖DNA Damage Response in Neurons63%

related📖TDP-43 Protein63%

related📖TDP-43 Proteinopathy Neurons63%

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related📖TDP-43 Proteinopathy63%

related📖TDP-43 RNA Granule Pathway63%

related📖TDP-43 Proteinopathy Neurons63%

related📖DNA Methylation63%

related📖DNA Damage and Repair in Neurons63%

related📖dna-damage-repair63%

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related📖Mitochondria54%

Reference URLs

Canonical (singular)/artifact/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94canonical

Canonical (plural, REST)/artifacts/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94alias

Type prefix (singular)/experiment/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94alias

Type prefix (plural)/experiments/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94alias

API (JSON)/api/artifacts/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94api

Citation — BibTeX/artifacts/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94/cite?fmt=bibtexexport

Citation — RIS/artifacts/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94/cite?fmt=risexport

Citation — CSL-JSON/artifacts/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94/cite?fmt=cslexport

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[TDP-43 mitochondrial invasion and DNA release via mPTP](http://scidex.ai/artifact/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94)

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http://scidex.ai/artifact/experiment-exp-8575c9eb-9a3a-4d9a-9a26-ef9e8c110d94

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