TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons

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TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons

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experiment Created: 2026-04-06T12:28:40 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-aaf75848-e1d3-41b1-b131-3

🧫 Experiment Protocol Cell Biologyproposed

Related Entities

TARDBP

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:28:40.541916'}
p_value	None
protocol	iPSC differentiation to motor neurons, TDP-43 overexpression or mutation, mitochondrial imaging, DNA release assays, cGAS/STING pathway analysis
effect_size	None
sample_size	None
source_pmid	33031745
extracted_at	2026-04-06T05:28:40.538767
_schema_version	1
experiment_type	cell_biology
success_criteria	Demonstration of TDP-43 mitochondrial localization, mtDNA release, and cGAS/STING pathway activation
expected_outcomes	TDP-43 invasion into mitochondria should trigger mtDNA release via mPTP opening, leading to cGAS activation and downstream inflammatory signaling
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

117

Outgoing

122

0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 3 nodes, 17 edges

derives from (1)

experiment-exp-aaf75848-e1d3-4→paper-33031745

supports (2)

paper-33031745→hypothesis-h-7e846cebhypothesis-h-7e846ceb→paper-33031745

This artifact has no version history yet.

Linked Artifacts (233)

derives_from📄TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activa100%

related🧪Cryptic Exon Silencing Restoration100%

related🧪Cross-Seeding Prevention Strategy100%

mentions📖TARDBP — TAR DNA Binding Protein 4390%

mentions📖TARDBP Protein (TDP-43)80%

mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis80%

mentions📖TARDBP/TDP-43 Protein80%

mentions📖TARDBP — TAR DNA Binding Protein 4380%

related📖TARDBP/TDP-43 Protein72%

related📖TARDBP Protein (TDP-43)72%

mentions📖DNA Repair Therapy for Neurodegeneration70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖DNA Ligase IV Protein70%

mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%

mentions📖ALS Motor Neuron Vulnerability70%

mentions📖dna-damage-repair70%

mentions📖DNA Damage Repair Investment Landscape70%

mentions📖STING Protein70%

mentions📖ALS Pipeline Companies70%

mentions📖ALS Knowledge Gaps70%

mentions📖ALS Pipeline70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

mentions📖DNA Damage and Repair Dysfunction in PSP70%

mentions📖ALS Progression Rate Heterogeneity70%

mentions📖TDP-43 Aggregate Neurons70%

mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%

mentions📖ALS Clinical Trials Consortium (NEALS)70%

mentions📖STING Inhibitor Therapy in Neurodegeneration70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖ALS Communication Brain-Computer Interfaces70%

mentions📖TDP-43 PET Ligand Development for FTD and ALS70%

mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%

mentions📖ALS Therapeutic Landscape — Programs by Phase and Modality70%

mentions📖ALS Mechanistic Pathway70%

mentions📖ALS Progression Rate Heterogeneity70%

mentions📖ALS Combination Therapy Matrix70%

mentions📖ALS Therapeutics70%

mentions📖ALS-FTD-Parkinsonism Comparison Matrix70%

mentions📖tdp-43-fus-rna-proteinopathy-comparison70%

mentions📖DNA Damage Response in Alzheimer's Disease70%

mentions📖ALS Immune Signature Stratification for Clinical Trials70%

mentions📖ALS Disease Spectrum vs Molecular Subtypes70%

mentions📖ALS RNA Metabolism and Proteostasis Failure70%

mentions📖TDP-43 Proteinopathy in ALS70%

mentions📖STING Protein70%

mentions📖DNA Damage Response in Alzheimer's Disease70%

mentions📖TDP-43 Splicing Modulation Therapy70%

mentions📖ALS Progression Rate Heterogeneity — mechanism and biomarker70%

mentions📖ALS Trial Failures Knowledge Gap70%

mentions📖DNA Ligase III Protein70%

mentions📖ALS Knowledge Gaps Ranked List70%

mentions📖ALS Cure Roadmap70%

mentions📖ALS Progression Trajectories70%

mentions📖ALS Treatment Strategies70%

mentions📖ALS vs FTD: Comparative Investment Analysis70%

mentions📖TDP-43 Protein70%

mentions📖ALS Cure Roadmap70%

mentions📖ALS Failed Approaches Analysis70%

mentions📖DNA Damage Response in Corticobasal Syndrome70%

mentions📖TDP-43 PET Ligand Development for Frontotemporal Dementia70%

mentions📖DNA Damage Response in Neurons70%

mentions📖ALS-FTD Spectrum70%

mentions📖TDP-43 Proteinopathy70%

mentions📖TDP-43 Protein70%

mentions📖DNA Damage Response in Parkinson's Disease70%

mentions📖TDP-43 Pathology Reversibility in ALS70%

mentions📖STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease70%

mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

mentions📖DNA Damage Response and Repair in Neurodegeneration70%

mentions📖DNA-PKcs (PRKDC) Protein70%

mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%

mentions📖DNA Methylation Biomarkers in Neurodegeneration70%

mentions📖TDP-43 Protein70%

mentions📖ALS-FTD Spectrum: Unified Pathogenic Mechanisms70%

related📖Amyotrophic Lateral Sclerosis70%

mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%

mentions📖ALS Treatment Overview70%

mentions📖ALS Regional Onset and Spread: Network-Level Staging Model70%

mentions📖ALS Therapeutic Scorecard70%

mentions📖DNA Damage Response Impairment Pathway70%

mentions📖DNA Repair Mechanisms in Neurodegeneration70%

mentions📖STING Gene70%

mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%

mentions📖ALS Biomarker-to-Mechanism Mapping70%

mentions📖TDP-43 Proteinopathy Investment Landscape70%

mentions📖DNA Damage Response in Corticobasal Syndrome70%

mentions📖DNA Sensing Pathways in Neurodegeneration70%

mentions📖DNA Damage Repair Therapy - Biomarker Guided70%

mentions📖DNA Methylation70%

mentions📖DNA Damage Response in 4R-Tauopathies70%

mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%

mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%

mentions📖ALS Biomarkers and Disease Monitoring70%

mentions📖DNA Methylation in Neurodegeneration70%

mentions📖ALS-FTD Overlap Neurons70%

mentions📖ALS Trial Failure Analysis70%

mentions📖DNA Damage Repair Therapy for Neurodegeneration70%

mentions📖DNA Damage Response in Neurodegeneration70%

mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%

mentions📖ALS Association70%

mentions📖ALS-FTD Overlap: Mechanistic Pathways70%

mentions📖ALS Regional Onset and Spread Patterns70%

mentions📖TDP-43 RNA Granule Pathway70%

mentions📖DNA Damage and Repair in Neurons70%

related📖ALS Cure Roadmap63%

related📖ALS Knowledge Gaps63%

related📖TDP-43 Proteinopathy Neurons63%

related📖ALS Progression Trajectories63%

related📖dna-damage-repair63%

related📖ALS Mechanistic Pathway63%

related📖TDP-43 Proteinopathy63%

related📖ALS Trial Failure Analysis63%

related📖STING Protein63%

related📖TDP-43 RNA Granule Pathway63%

related📖ALS Combination Therapy Matrix63%

related📖ALS Pipeline63%

related📖ALS Failed Approaches Analysis63%

related📖ALS Cure Roadmap63%

related📖DNA Methylation63%

related📖DNA-PKcs (PRKDC) Protein63%

related📖ALS Therapeutic Scorecard63%

related📖ALS Knowledge Gaps Ranked List63%

related📖ALS-FTD Spectrum63%

related📖TDP-43 Protein63%

related📖ALS Trial Failures Knowledge Gap63%

related📖ALS Therapeutics63%

related📖TDP-43 Protein63%

related📖ALS-FTD Overlap Neurons63%

related📖TDP-43 Protein63%

related📖DNA Ligase III Protein63%

related📖ALS Pipeline Companies63%

related📖ALS Treatment Overview63%

related📖ALS Treatment Strategies63%

related📖TDP-43 Proteinopathy in ALS63%

related📖ALS Motor Neuron Vulnerability63%

related📖ALS Association63%

related📖DNA Ligase IV Protein63%

related📖DNA Damage Response in Neurons63%

related📖TDP-43 Protein63%

related📖DNA Damage and Repair in Neurons63%

related📖TDP-43 Proteinopathy Neurons63%

related📖STING Gene63%

related📖TDP-43 Aggregate Neurons63%

related📖STING Protein63%

mentions📖Motor Neurons60%

mentions📖Bulbar Amyotrophic Lateral Sclerosis60%

mentions📖FUS Mutations in Amyotrophic Lateral Sclerosis60%

mentions📖Amyotrophic Lateral Sclerosis (ALS) Genetic Variants60%

mentions📖Events60%

mentions📖Mitochondria60%

mentions📖SOD1 Mutations in Amyotrophic Lateral Sclerosis60%

mentions📖Spinal Amyotrophic Lateral Sclerosis60%

mentions📖Amyotrophic Lateral Sclerosis (ALS)60%

mentions📖neuroinflammation60%

related📖neuroinflammation54%

related📖Motor Neurons54%

related📖Mitochondria54%

related📖Events54%

mentions📖STING Gene50%

Reference URLs

Canonical (singular)/artifact/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9ccanonical

Canonical (plural, REST)/artifacts/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9calias

Type prefix (singular)/experiment/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9calias

Type prefix (plural)/experiments/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9calias

API (JSON)/api/artifacts/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9capi

Citation — BibTeX/artifacts/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9c/cite?fmt=bibtexexport

Citation — RIS/artifacts/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9c/cite?fmt=risexport

Citation — CSL-JSON/artifacts/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9c/cite?fmt=cslexport

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Markdown link

[TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons](http://scidex.ai/artifact/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9c)

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http://scidex.ai/artifact/experiment-exp-aaf75848-e1d3-41b1-b131-3e2c13730e9c

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