Entities

Overview

This index provides a clean navigation layer for the `entities` section of NeuroWiki. It currently lists 185 published entities pages and is regenerated from live Wiki.js metadata to avoid recursive markdown-link corruption.

_Total: 185 pages_

All Pages

Overview

This index provides a clean navigation layer for the `entities` section of NeuroWiki. It currently lists 185 published entities pages and is regenerated from live Wiki.js metadata to avoid recursive markdown-link corruption.

_Total: 185 pages_

All Pages

• [ABCA7 (ATP-Binding Cassette Transporter A7)](/entities/abca7)
• [AC-193](/entities/ac-193)
• [Acetylcholine](/entities/acetylcholine)
• [Adenosine A2A Receptor](/entities/adenosine-a2a-receptor)
• [Aduhelm](/entities/aduhelm)
• [AL001](/entities/al001)
• [AMPK (AMP-Activated Protein Kinase)](/entities/ampk)
• [Amyloid PET Imaging](/entities/amyloid-pet)
• [Amyloid Precursor Protein (APP)](/entities/app-protein)
• [Amyloid-Related Imaging Abnormalities (ARIA)](/entities/aria-imaging)
• [Apoptosis in Neurodegeneration](/entities/apoptosis)
• [Astrocytes](/entities/astrocytes)
• [ATP7B Gene](/entities/atp7b-gene)
• [Atrophin-1 Protein](/entities/atrophin-1)
• [Autonomic Nervous System](/entities/autonomic-nervous-system)
• [Autophagy](/entities/autophagy)
• [BACE1 (Beta-Secretase)](/entities/bace1)
• [BIIB080 (MAPTRx)](/entities/biiib080)
• [BIIB122](/entities/biiib122)
• [Blarcamesine](/entities/blarcamesine)
• [Blood-Brain Barrier](/entities/blood-brain-barrier)
• [BNIP1 Protein (BCL2-Interacting Protein 1)](/entities/bnip1-protein)
• [Brain Insulin Signaling](/entities/brain-insulin-signaling)
• [BSE (Bovine Spongiform Encephalopathy)](/entities/bse)
• [Buntanetap](/entities/buntanetap)
• [Brain Health Roundtable and AADAPT Act](/entities/brain-health-roundtable-aadapt-act)
• [C9orf72 (Chromosome 9 Open Reading Frame 72)](/entities/c9orf72)
• [C9orf72 Protein (Chromosome 9 Open Reading Frame 72)](/entities/c9orf72-protein)
• [Calpains](/entities/calpains)
• [Caspases](/entities/caspases)
• [Cholinesterase Inhibitors](/entities/cholinesterase-inhibitors)
• [CNTFR Gene](/entities/cntfr-gene)
• [Complement System](/entities/complement-system)
• [Crenezumab](/entities/crenezumab)
• [DIAN-Observational Study (DIAN-O)](/entities/dian-observational-study)
• [DJ-1 (PARK7)](/entities/dj1)
• [DNA Methylation](/entities/dna-methylation)
• [DNL151](/entities/dnl151)
• [DNL310](/entities/dnl310)
• [Dominantly Inherited Alzheimer Network (DIAN)](/entities/dian-study)
• [Donanemab (Kisunla)](/entities/donanemab)
• [Donepezil](/entities/donepezil)
• [Dopamine](/entities/dopamine)
• [Dopaminergic Neurons](/entities/dopaminergic-neurons)
• [Entities Overview](/entities/overview)
• [Entities Quality Rankings](/entities/quality-rankings)
• [Excitotoxicity](/entities/excitotoxicity)
• [Exosomes](/entities/exosomes)
• [Expand Hsp90 content](/entities/hsp90-protein)
• [Expand Microtubules content](/entities/microtubules)
• [FDG PET Imaging](/entities/fdg-pet)
• [Ferroptosis](/entities/ferroptosis)
• [Fosramatine](/entities/fosramatine)
• [FPN1 (Ferroportin)](/entities/fpn1)
• [FUS (Fused in Sarcoma)](/entities/fus)
• [FUS Protein (Fused in Sarcoma)](/entities/fus-protein)
• [Gamma-Aminobutyric Acid (GABA)](/entities/gaba)
• [Gamma-Secretase Complex](/entities/gamma-secretase)
• [Gantenerumab](/entities/gantenerumab)
• [GBA Gene](/entities/gba)
• [GBA1 (Glucocerebrosidase)](/entities/gba1)
• [Glial Cell Line-Derived Neurotrophic Factor (GDNF)](/entities/gdnf)
• [Glial Fibrillary Acidic Protein (GFAP)](/entities/gfap)
• [Glial Fibrillary Acidic Protein (GFAP)](/entities/glial-fibrillary-acidic-protein)
• [GLP-1 Receptor (Glucagon-Like Peptide-1 Receptor)](/entities/glp1-receptor)
• [Glutamate](/entities/glutamate)
• [Glymphatic System](/entities/glymphatic-system)
• [GRM1 Gene](/entities/grm1-gene)
• [GRM5 Gene](/entities/grm5-gene)
• [GRM7 Gene](/entities/grm7-gene)
• [GRN (Progranulin)](/entities/grn)
• [GSK-3β](/entities/gsk3-beta)
• [GT-02287](/entities/gt-02287)
• [Gut-Brain Axis](/entities/gut-brain-axis)
• [HDAC6 (Histone Deacetylase 6)](/entities/hdac6)
• [Heat Shock Proteins](/entities/heat-shock-proteins)
• [Hepcidin (HAMP)](/entities/hepcidin)
• [HEXA (Hexosaminidase A)](/entities/hexa)
• [Histamine](/entities/histamine)
• [Histone Deacetylase (HDAC) Enzymes](/entities/hdac-enzymes)
• [Histone Deacetylases (HDACs)](/entities/histone-deacetylase)
• [Histone Methylation](/entities/histone-methylation)
• [Histone Modifications](/entities/histone-modifications)
• [IL6 Gene](/entities/il6)
• [Insulin Receptor Substrate 1 (IRS-1)](/entities/irs-1)
• [Interleukin-6 (IL-6)](/entities/interleukin-6)
• [IRS-1 (Insulin Receptor Substrate 1)](/entities/irs1)
• [LAF1 Protein (La-Related Protein 1)](/entities/laf1-protein)
• [Lecanemab (Leqembi)](/entities/lecanemab)
• [Long-Term Potentiation (LTP)](/entities/ltp)
• [LRRK2 (Leucine-Rich Repeat Kinase 2)](/entities/lrrk2)
• [LRRK2 Protein (Leucine-Rich Repeat Kinase 2)](/entities/lrrk2-protein)
• [Microbiome](/entities/microbiome)
• [Microglia](/entities/microglia)
• [Microglia in Neurodegeneration](/entities/microglia-in-neurodegeneration)
• [Mitochondria](/entities/mitochondria)
• [Mitochondrial Dynamics](/entities/mitochondrial-dynamics)
• [MOSPD1 Protein (Motile Sperm Domain-Containing Protein 1)](/entities/mospd1-protein)
• [MSH3 (MutS Homolog 3)](/entities/msh3)
• [MTHFR (Methylenetetrahydrofolate Reductase)](/entities/mthfr)
• [mTOR (Mechanistic Target of Rapamycin)](/entities/mtor)
• [Necroptosis](/entities/necroptosis)
• [Neprilysin (NEP)](/entities/neprilysin)
• [Neurogenesis](/entities/neurogenesis)
• [Neurons](/entities/neurons)
• [NF-κB (Nuclear Factor Kappa B)](/entities/nf-kb)
• [NGF Gene](/entities/ngf)
• [NLRP3 Inflammasome](/entities/nlrp3-inflammasome)
• [NMDA Receptor](/entities/nmda-receptor)
• [Norepinephrine (Noradrenaline)](/entities/norepinephrine)
• [NTRK1 Gene](/entities/ntrk1)
• [Nucleus Basalis of Meynert](/entities/nucleus-basalis-meynert)
• [Oligodendrocytes](/entities/oligodendrocytes)
• [p62/SQSTM1 (Sequestosome-1)](/entities/p62-sqstm1)
• [Parkin (PARK2)](/entities/parkin-protein)
• [PBKR03](/entities/pbkr03)
• [PC12 Cell Line](/entities/pc12-cell-line)
• [PINK1 (PTEN-Induced Kinase 1)](/entities/pink1-protein)
• [PLD4 (Phospholipase D Family Member 4)](/entities/pld4)
• [PNT001](/entities/pnt001)
• [PP2A](/entities/pp2a)
• [PPAR (Peroxisome Proliferator-Activated Receptor)](/entities/ppar)
• [PR001](/entities/pr001)
• [Prasinezumab](/entities/prasinezumab)
• [Presenilin 1 (PSEN1)](/entities/psen1)
• [Presenilin 2 (PSEN2)](/entities/psen2)
• [Presenilin-1 (PS1)](/entities/presenilin-1)
• [Prion-Like Spreading](/entities/prion-like-spreading)
• [PRNP (Prion Protein Gene)](/entities/prnp-gene)
• [PRNP Gene](/entities/prnp)
• [PRX005](/entities/prx005)
• [PRX012](/entities/prx012)
• [PSD-95 (Postsynaptic Density Protein 95)](/entities/psd-95)
• [Reactive Oxygen Species (ROS)](/entities/reactive-oxygen-species)
• [Reactive Oxygen Species (ROS)](/entities/ros)
• [Remternetug](/entities/remternetug)
• [Rivastigmine](/entities/rivastigmine)
• [Ryanodine Receptor](/entities/ryanodine-receptor)
• [SEL1L](/entities/sel1l)
• [Semorinemab](/entities/semorinemab)
• [Serotonin (5-Hydroxytryptamine, 5-HT)](/entities/serotonin)
• [Simufilam](/entities/simufilam)
• [SIRT1 (Sirtuin 1)](/entities/sirt1)
• [SNX5 (Sorting Nexin 5)](/entities/snx5)
• [SOD1 (Superoxide Dismutase 1)](/entities/sod1)
• [SOD1 Protein (Superoxide Dismutase 1)](/entities/sod1-protein)
• [SH-SY5Y Cell Line](/entities/sh-sy5y)
• [SORL1 (Sortilin-Related Receptor 1)](/entities/sorl1)
• [SPG7 — Spastic Paraplegia 7](/entities/spg7)
• [SQSTM1/p62](/entities/sqstm1-p62)
• [STAT3 (Signal Transducer and Activator of Transcription 3)](/entities/stat3)
• [Tau Oligomers](/entities/tau-oligomers)
• [Tau PET Imaging in Neurodegenerative Disease](/entities/tau-pet)
• [TFEB (Transcription Factor EB)](/entities/tfeb)
• [TLR4 (Toll-Like Receptor 4)](/entities/tlr4)
• [TNF Gene](/entities/tnf)
• [TREM2 Protein (Triggering Receptor Expressed on Myeloid Cells 2)](/entities/trem2-protein)
• [TrkB Signaling](/entities/trkb-signaling)
• [Tumor Necrosis Factor (TNF)](/entities/tumor-necrosis-factor)
• [UB-312](/entities/ub-312)
• [UBQLN2 Protein (Ubiquilin-2)](/entities/ubqln2-protein)
• [Unfolded Protein Response](/entities/unfolded-protein-response)
• [Unfolded Protein Response (UPR)](/entities/upr)
• [VIRMA (KIAA1429)](/entities/virma-kiaa1429)
• [XPro1595](/entities/xpro1595)
• [α-Tubulin (Alpha-Tubulin)](/entities/alpha-tubulin)

Additional Entity Pages

• [RNF128 (Graf1/XTP3) Gene](/entities/rnf128)

Coverage Gaps

Missing Entity Categories

• Metabolic Entities: Limited coverage of metabolic pathway components (e.g., glycolysis enzymes, TCA cycle components)
• Epigenetic Entities: Missing many histone modifiers, chromatin regulators beyond existing coverage
• Ion Channel Entities: Few voltage-gated calcium/potassium channel entities indexed
• Neurotrophic Factor Entities: Limited coverage of GDNF family ligands and receptors beyond existing

Organization Issues

• Mixed content: proteins, drugs, pathways, concepts all in same section
• Could benefit from sub-indexes (protein entities, drug entities, pathway entities)
• Many gene aliases not cross-linked

Related Index Needs

• Could benefit from drug pipeline sub-index
• Need better pathway-component cross-linking to mechanisms section

Related Sections

• [Proteins](/proteins) — Protein components of molecular entities
• [Genes](/genes) — Gene products forming entities
• [Mechanisms](/mechanisms) — Pathways involving these entities
• [Therapeutics](/therapeutics) — Targeting these entities

See Also

• [NeuroWiki Home](/home)
• [All Pages](/all-pages)
• [Diseases Index](/diseases)
• [Mechanisms Index](/mechanisms)
• [Therapeutics Index](/therapeutics)
• [Entities Index](/entities)

References

Pathway Diagram

The following diagram shows the key molecular relationships involving Entities discovered through SciDEX knowledge graph analysis:

Related Hypotheses

From the [SciDEX Exchange](/exchange) — scored by multi-agent debate

• [Nutrient-Sensing Epigenetic Circuit Reactivation](/hypothesis/h-4bb7fd8c) — <span style="color:#81c784;font-weight:600">0.79</span> · Target: SIRT1
• [Selective Acid Sphingomyelinase Modulation Therapy](/hypothesis/h-de0d4364) — <span style="color:#81c784;font-weight:600">0.77</span> · Target: SMPD1
• [TREM2-Dependent Microglial Senescence Transition](/hypothesis/h-61196ade) — <span style="color:#81c784;font-weight:600">0.76</span> · Target: TREM2
• [APOE-Dependent Autophagy Restoration](/hypothesis/h-51e7234f) — <span style="color:#81c784;font-weight:600">0.73</span> · Target: MTOR
• [Cell-Type Specific TREM2 Upregulation in DAM Microglia](/hypothesis/h-seaad-51323624) — <span style="color:#81c784;font-weight:600">0.70</span> · Target: TREM2
• [Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming](/hypothesis/h-f3fb3b91) — <span style="color:#81c784;font-weight:600">0.67</span> · Target: TLR4
• [APOE-TREM2 Interaction Modulation](/hypothesis/h-180807e5) — <span style="color:#81c784;font-weight:600">0.66</span> · Target: TREM2
• [Astrocyte-Mediated Neuronal Epigenetic Rescue](/hypothesis/h-8fe389e8) — <span style="color:#81c784;font-weight:600">0.64</span> · Target: HDAC

Related Analyses:

• [Lipid raft composition changes in synaptic neurodegeneration](/analysis/SDA-2026-04-01-gap-lipid-rafts-2026-04-01) &#x1f504;