microglial priming as a partially upstream causal node rather than a pure disease-stage correlate requires proximal validation

graph TD
    microglial_priming["microglial priming"] -->|causes| neurodegeneration["neurodegeneration"]
    TREM2["TREM2"] -->|regulates| microglial_priming_1["microglial priming"]
    microglial_priming_2["microglial priming"] -->|risk factor for| Alzheimer_disease["Alzheimer disease"]
    microglial_priming_3["microglial priming"] -->|risk factor for| Parkinson_disease["Parkinson disease"]
    microglial_priming_4["microglial priming"] -->|risk factor for| ALS["ALS"]
    microglial_priming_5["microglial priming"] -->|risk factor for| multiple_sclerosis["multiple sclerosis"]
    CSF_cytokines["CSF cytokines"] -->|biomarker for| microglial_priming_6["microglial priming"]
    cell_type_specific_Mendel["cell-type-specific Mendelian randomization"] -->|associated with| microglial_priming_causal["microglial priming causality"]
    scVelo_trajectory_analysi["scVelo trajectory analysis"] -->|associated with| microglial_priming_causal_7["microglial priming causality"]
    longitudinal_CSF_cytokine["longitudinal CSF cytokine Granger causality"] -->|associated with| microglial_priming_causal_8["microglial priming causality"]
    CX3CR1["CX3CR1"] -->|regulates| microglial_priming_9["microglial priming"]
    C1QA["C1QA"] -->|modulates| microglial_priming_10["microglial priming"]
    style microglial_priming fill:#4fc3f7,stroke:#333,color:#000
    style neurodegeneration fill:#4fc3f7,stroke:#333,color:#000
    style TREM2 fill:#ce93d8,stroke:#333,color:#000
    style microglial_priming_1 fill:#4fc3f7,stroke:#333,color:#000
    style microglial_priming_2 fill:#4fc3f7,stroke:#333,color:#000
    style Alzheimer_disease fill:#ef5350,stroke:#333,color:#000
    style microglial_priming_3 fill:#4fc3f7,stroke:#333,color:#000
    style Parkinson_disease fill:#ef5350,stroke:#333,color:#000
    style microglial_priming_4 fill:#4fc3f7,stroke:#333,color:#000
    style ALS fill:#ef5350,stroke:#333,color:#000
    style microglial_priming_5 fill:#4fc3f7,stroke:#333,color:#000
    style multiple_sclerosis fill:#ef5350,stroke:#333,color:#000
    style CSF_cytokines fill:#4fc3f7,stroke:#333,color:#000
    style microglial_priming_6 fill:#4fc3f7,stroke:#333,color:#000
    style cell_type_specific_Mendel fill:#4fc3f7,stroke:#333,color:#000
    style microglial_priming_causal fill:#4fc3f7,stroke:#333,color:#000
    style scVelo_trajectory_analysi fill:#4fc3f7,stroke:#333,color:#000
    style microglial_priming_causal_7 fill:#4fc3f7,stroke:#333,color:#000
    style longitudinal_CSF_cytokine fill:#4fc3f7,stroke:#333,color:#000
    style microglial_priming_causal_8 fill:#4fc3f7,stroke:#333,color:#000
    style CX3CR1 fill:#ce93d8,stroke:#333,color:#000
    style microglial_priming_9 fill:#4fc3f7,stroke:#333,color:#000
    style C1QA fill:#4fc3f7,stroke:#333,color:#000
    style microglial_priming_10 fill:#4fc3f7,stroke:#333,color:#000