Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C1QC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
C1QC is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in, biomarker for. Associated with AD, ALI, ALS. Connected to 65 entities in the SciDEX knowledge graph.
| Gene Symbol | C1QC |
| Function | The C1QC gene encodes the C chain of the C1q protein, which is the recognition component of the classical complement pathway. |
| Primary Expression | various tissues, with high expression in: |
| Molecular Weight | 26 kDa |
| Amino Acids | 245 aa |
| Pathways | Complement |
| Ensembl ID | ENSG00000166922 |
| GeneCards | C1QC |
| Human Protein Atlas | C1QC |
| Amyotrophic Lateral Sclerosis | C1q is implicated in the inflammatory response and may be involved in motor neuron degeneration. |
| Age-Related Macular Degeneration | Genetic variants in C1QC are associated with AMD risk. |
| Brain | Local expression by microglia, astrocytes, and neurons. C1q is synthesized in the brain and can be upregulated by inflammatory stimuli. |
| Liver | Primary site of complement protein synthesis |
| Immune cells | Macrophages, monocytes, and dendritic cells |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Interactions | C1Q, C1QA, CD14, CD163, CTSB, CTSL |
| KG Connections | 220 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
C1QC["<b>C1QC</b>"]
Atherosclerosis{"Atherosclerosis"}
C1QC -->|"associated with"| Atherosclerosis
Stroke{"Stroke"}
C1QC -->|"associated with"| Stroke
Ms{"Ms"}
C1QC -->|"associated with"| Ms
Alzheimer{"Alzheimer"}
C1QC -->|"biomarker for"| Alzheimer
Als{"Als"}
C1QC -->|"biomarker for"| Als
C1QC -->|"activates"| Atherosclerosis
C1QC -->|"activates"| Stroke
Hepatitis{"Hepatitis"}
C1QC -->|"associated with"| Hepatitis
C1QC -->|"associated with"| Als
Cirrhosis{"Cirrhosis"}
C1QC -->|"associated with"| Cirrhosis
Carcinoma{"Carcinoma"}
C1QC -->|"associated with"| Carcinoma
Autoimmune{"Autoimmune"}
C1QC -->|"associated with"| Autoimmune
GBM["GBM"]
GBM -->|"associated with"| C1QC
C1Q["C1Q"]
C1Q -->|"activates"| C1QC
C1QA["C1QA"]
C1QA -->|"activates"| C1QC
C1Q -->|"inhibits"| C1QC
SPI1["SPI1"]
SPI1 -->|"expressed in"| C1QC
GENES["GENES"]
GENES -->|"associated with"| C1QC
APOE["APOE"]
APOE -->|"activates"| C1QC
COMPLEMENT["COMPLEMENT"]
COMPLEMENT -->|"therapeutic target"| C1QC
COMPLEMENT -->|"activates"| C1QC
LDL["LDL"]
LDL -->|"expressed in"| C1QC
STROKE["STROKE"]
STROKE -->|"associated with"| C1QC
COMPLEMENT -->|"inhibits"| C1QC
style C1QC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's Disease | biomarker_for | disease | 0.95 |
| Hallmark_Complement | involved_in | pathway | 0.90 |
| ATHEROSCLEROSIS | associated_with | entity | 0.90 |
| Cognitive Performance | correlates_with | phenotype | 0.85 |
| Atherosclerotic Plaques | biomarker_for | disease | 0.85 |
| Atherosclerosis | risk_factor_for | disease | 0.85 |
| Atherosclerosis | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Alzheimer | biomarker_for | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Stroke | activates | disease | 0.65 |
| Hepatitis | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Cirrhosis | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Autoimmune | associated_with | disease | 0.65 |
| ALS | biomarker_for | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Senescence | associated_with | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| alzheimer_disease | associated_with | disease | 0.64 |
| SPI1 | expressed_in | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| C1Q | activates | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| C1S | therapeutic_target | gene | 0.60 |
| C1Q | therapeutic_target | gene | 0.60 |
| C1QA | activates | gene | 0.60 |
| TAU | biomarker_for | gene | 0.60 |
| C1Q | inhibits | gene | 0.60 |
| C1S | regulates | gene | 0.60 |
| C1QA | regulates | gene | 0.60 |
| CD47 | regulates | gene | 0.60 |
| C4B | biomarker_for | gene | 0.60 |
| ITGAM | biomarker_for | gene | 0.60 |
| C1QA | biomarker_for | gene | 0.60 |
| C1R | regulates | gene | 0.60 |
| C1QB | regulates | gene | 0.60 |
| SIRPA | regulates | gene | 0.60 |
| TYROBP | associated_with | gene | 0.60 |
| CD68 | biomarker_for | gene | 0.60 |
| TMEM119 | biomarker_for | gene | 0.60 |
| TREM2 | biomarker_for | gene | 0.60 |
| CYBB | biomarker_for | gene | 0.60 |
| AIF1 | biomarker_for | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SPI1 | regulates | entity | 0.85 |
| GBM | associated_with | gene | 0.60 |
| C1Q | activates | gene | 0.60 |
| C1QA | activates | gene | 0.60 |
| C1Q | inhibits | gene | 0.60 |
| SPI1 | expressed_in | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| C1QA | associated_with | entity | 0.60 |
| C1QA | expressed_in | entity | 0.60 |
| TAU | biomarker_for | gene | 0.60 |
| C1QB | regulates | gene | 0.60 |
| C1R | regulates | gene | 0.60 |
| SIRPA | regulates | gene | 0.60 |
| C1QB | biomarker_for | gene | 0.60 |
| TMEM119 | biomarker_for | gene | 0.60 |
| AIF1 | biomarker_for | gene | 0.60 |
| TYROBP | associated_with | gene | 0.60 |
| TREM2 | biomarker_for | gene | 0.60 |
| CD68 | biomarker_for | gene | 0.60 |
| CYBB | biomarker_for | gene | 0.60 |
| ITGAM | biomarker_for | gene | 0.60 |
| C1QA | biomarker_for | gene | 0.60 |
| APOC1 | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| COMPLEMENT | therapeutic_target | gene | 0.60 |
| COMPLEMENT | activates | gene | 0.60 |
| LDL | expressed_in | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| COMPLEMENT | inhibits | gene | 0.60 |
| AMYLOID | biomarker_for | gene | 0.60 |
| ALZHEIMER'S DISEASE | biomarker_for | gene | 0.60 |
| ALZHEIMER | biomarker_for | gene | 0.60 |
| ASTROCYTE | biomarker_for | gene | 0.60 |
| EXOSOMES | biomarker_for | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| RAS | inhibits | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| COMPLEMENT | regulates | gene | 0.60 |
| PHAGOCYTOSIS | associated_with | gene | 0.60 |
| COMPLEMENT | biomarker_for | gene | 0.60 |
| AGING | associated_with | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| C1QA | interacts_with | gene | 0.55 |
| C1QB | interacts_with | gene | 0.55 |
| C1QA | co_discussed | gene | 0.50 |
| C1QB | co_discussed | gene | 0.50 |
| APOE | expressed_in | gene | 0.50 |
| late | regulates | disease | 0.50 |
| MERTK | regulates | gene | 0.50 |
| C1QA | regulates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||