protein

C1QC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1QC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

217Connections
0Hypotheses
5Analyses
50Outgoing
50Incoming
0Experiments
6Debates

Summary

C1QC is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in, biomarker for. Associated with AD, ALI, ALS. Connected to 65 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolC1QC
FunctionThe C1QC gene encodes the C chain of the C1q protein, which is the recognition component of the classical complement pathway.
Primary Expressionvarious tissues, with high expression in:
Molecular Weight26 kDa
Amino Acids245 aa
PathwaysComplement
Ensembl IDENSG00000166922
GeneCardsC1QC
Human Protein AtlasC1QC
Amyotrophic Lateral SclerosisC1q is implicated in the inflammatory response and may be involved in motor neuron degeneration.
Age-Related Macular DegenerationGenetic variants in C1QC are associated with AMD risk.
BrainLocal expression by microglia, astrocytes, and neurons. C1q is synthesized in the brain and can be upregulated by inflammatory stimuli.
LiverPrimary site of complement protein synthesis
Immune cellsMacrophages, monocytes, and dendritic cells
Associated DiseasesAD, Aging, ALI, Als, Alzheimer
InteractionsAIF1, APOC1, APOE, C1Q, C1QA, C1QB
KG Connections217 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

C1QC

gene · 618 words

C1QC Protein

protein · 647 words

Pathway Diagram

graph TD
    C1QC["C1QC"]
    Atherosclerosis{"Atherosclerosis"}
    C1QC -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    C1QC -->|"associated with"| Stroke
    Ms{"Ms"}
    C1QC -->|"associated with"| Ms
    Alzheimer{"Alzheimer"}
    C1QC -->|"biomarker for"| Alzheimer
    Als{"Als"}
    C1QC -->|"biomarker for"| Als
    C1QC -->|"activates"| Atherosclerosis
    C1QC -->|"activates"| Stroke
    Hepatitis{"Hepatitis"}
    C1QC -->|"associated with"| Hepatitis
    C1QC -->|"associated with"| Als
    Cirrhosis{"Cirrhosis"}
    C1QC -->|"associated with"| Cirrhosis
    Carcinoma{"Carcinoma"}
    C1QC -->|"associated with"| Carcinoma
    Autoimmune{"Autoimmune"}
    C1QC -->|"associated with"| Autoimmune
    GBM["GBM"]
    GBM -->|"associated with"| C1QC
    C1Q["C1Q"]
    C1Q -->|"activates"| C1QC
    C1QA["C1QA"]
    C1QA -->|"activates"| C1QC
    C1Q -->|"inhibits"| C1QC
    SPI1["SPI1"]
    SPI1 -->|"expressed in"| C1QC
    GENES["GENES"]
    GENES -->|"associated with"| C1QC
    APOE["APOE"]
    APOE -->|"activates"| C1QC
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"therapeutic target"| C1QC
    COMPLEMENT -->|"activates"| C1QC
    LDL["LDL"]
    LDL -->|"expressed in"| C1QC
    STROKE["STROKE"]
    STROKE -->|"associated with"| C1QC
    COMPLEMENT -->|"inhibits"| C1QC
    style C1QC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (151)

TargetRelationTypeStr
Alzheimer's Diseasebiomarker_fordisease0.95
ATHEROSCLEROSISassociated_withentity0.90
complement cascadeactivatespathway0.90
Hallmark_Complementinvolved_inpathway0.90
Atherosclerotic Plaquesbiomarker_fordisease0.85

Incoming (66)

SourceRelationTypeStr
SPI1regulatesentity0.85
RELAregulatesprotein0.70
C1Qactivatesgene0.60
C1QAactivatesgene0.60
SPI1expressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604

Does C1q function differ based on subcellular localization or binding partner id

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.750

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

molecular biology | 2026-04-17 | 10 hypotheses Top: 0.445

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 7 hypotheses Top: 0.631

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (6)

Multi-agent debates referencing this entity

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

closed · Rounds: 4 · Score: 0.64 · 2026-04-28

Does C1q function differ based on subcellular localization or binding partner id

closed · Rounds: 4 · Score: 0.68 · 2026-04-25

While the study establishes C1QA and C1QC as diagnostic biomarkers and confirms

closed · Rounds: 4 · Score: 0.71 · 2026-04-21

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

closed · Rounds: 4 · Score: 0.74 · 2026-04-21

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 1.00 · 2026-04-19

The fundamental premise remains unvalidated despite extensive mechanistic specul

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning C1QC in their description or question text

No additional research found