protein

C1QC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1QC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

220Connections
0Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

C1QC is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in, biomarker for. Associated with AD, ALI, ALS. Connected to 65 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolC1QC
FunctionThe C1QC gene encodes the C chain of the C1q protein, which is the recognition component of the classical complement pathway.
Primary Expressionvarious tissues, with high expression in:
Molecular Weight26 kDa
Amino Acids245 aa
PathwaysComplement
Ensembl IDENSG00000166922
GeneCardsC1QC
Human Protein AtlasC1QC
Amyotrophic Lateral SclerosisC1q is implicated in the inflammatory response and may be involved in motor neuron degeneration.
Age-Related Macular DegenerationGenetic variants in C1QC are associated with AMD risk.
BrainLocal expression by microglia, astrocytes, and neurons. C1q is synthesized in the brain and can be upregulated by inflammatory stimuli.
LiverPrimary site of complement protein synthesis
Immune cellsMacrophages, monocytes, and dendritic cells
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
InteractionsC1Q, C1QA, CD14, CD163, CTSB, CTSL
KG Connections220 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

C1QC

gene · 618 words

Complement Activation in Corticobasal Degeneration

mechanism · 3025 words

SPI1 Gene - PU.1

gene · 2569 words

C1QA Gene — Complement Component 1q A Chain

gene · 2340 words

Complement Dysregulation in CBS and 4R Tauopathies

mechanism · 2071 words

CBS Single-Cell Transcriptomics Mechanisms

mechanism · 1481 words

Pathway Diagram

graph TD
    C1QC["<b>C1QC</b>"]
    Atherosclerosis{"Atherosclerosis"}
    C1QC -->|"associated with"| Atherosclerosis
    Stroke{"Stroke"}
    C1QC -->|"associated with"| Stroke
    Ms{"Ms"}
    C1QC -->|"associated with"| Ms
    Alzheimer{"Alzheimer"}
    C1QC -->|"biomarker for"| Alzheimer
    Als{"Als"}
    C1QC -->|"biomarker for"| Als
    C1QC -->|"activates"| Atherosclerosis
    C1QC -->|"activates"| Stroke
    Hepatitis{"Hepatitis"}
    C1QC -->|"associated with"| Hepatitis
    C1QC -->|"associated with"| Als
    Cirrhosis{"Cirrhosis"}
    C1QC -->|"associated with"| Cirrhosis
    Carcinoma{"Carcinoma"}
    C1QC -->|"associated with"| Carcinoma
    Autoimmune{"Autoimmune"}
    C1QC -->|"associated with"| Autoimmune
    GBM["GBM"]
    GBM -->|"associated with"| C1QC
    C1Q["C1Q"]
    C1Q -->|"activates"| C1QC
    C1QA["C1QA"]
    C1QA -->|"activates"| C1QC
    C1Q -->|"inhibits"| C1QC
    SPI1["SPI1"]
    SPI1 -->|"expressed in"| C1QC
    GENES["GENES"]
    GENES -->|"associated with"| C1QC
    APOE["APOE"]
    APOE -->|"activates"| C1QC
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"therapeutic target"| C1QC
    COMPLEMENT -->|"activates"| C1QC
    LDL["LDL"]
    LDL -->|"expressed in"| C1QC
    STROKE["STROKE"]
    STROKE -->|"associated with"| C1QC
    COMPLEMENT -->|"inhibits"| C1QC
    style C1QC fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (156)

TargetRelationTypeStr
Alzheimer's Diseasebiomarker_fordisease0.95
Hallmark_Complementinvolved_inpathway0.90
ATHEROSCLEROSISassociated_withentity0.90
Cognitive Performancecorrelates_withphenotype0.85
Atherosclerotic Plaquesbiomarker_fordisease0.85

Incoming (64)

SourceRelationTypeStr
SPI1regulatesentity0.85
GBMassociated_withgene0.60
C1Qactivatesgene0.60
C1QAactivatesgene0.60
C1Qinhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found