gene 683 words KG: C1QB 2026-03-24
kind:genesection:genesstate:published
Contents

C1QB — Complement Component 1Q Beta

🧬 Gene Info
Gene SymbolC1QB
Full NameC1QB — Complement Component 1Q Beta
Chromosome1p36.12.
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe liver as the main source of circulating C1q
Amino Acids245 aa
Exons2
PathwaysComplement, Immune Response
NCBI Gene ID713
GeneCardsC1QB
Human Protein AtlasC1QB
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
InteractionsMET, C1Q, SOD1, HSP27, CD47, SIRPA
KG Connections250 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (14)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54

Related Analyses (10)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived

Related Experiments (8)

Single-cell RNA sequencing analysis of human atherosclerotic
exploratory · proposed · Score: 0.90
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40

See Also (6)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: therapeutic_target
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_with
C1QA Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

C1QB interacts_with MET
C1QB interacts_with C1Q
C1QB activates SOD1
C1QB interacts_with HSP27
C1QB regulates CD38
C1QB regulates CD163
C1QB regulates CXCL10
C1QB co_discussed C1QC
C1QB co_discussed C1R
C1QB co_discussed C1S