gene

C1QB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C1QB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

250Connections
1Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

C1QB is a gene implicated in neurodegeneration research. Key relationships include: regulates, interacts with, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Carcinoma. Connected to 33 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolC1QB
Full NameC1QB — Complement Component 1Q Beta
Chromosome1p36.12.
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe liver as the main source of circulating C1q
Amino Acids245 aa
Exons2
PathwaysComplement, Immune Response
NCBI Gene ID713
GeneCardsC1QB
Human Protein AtlasC1QB
Associated DiseasesALS, Aging, Alzheimer, Atherosclerosis, Cancer
InteractionsMET, C1Q, SOD1, HSP27, CD47, SIRPA
KG Connections250 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

C1QB — Complement Component 1Q Beta

gene · 683 words

Complement Activation in Corticobasal Degeneration

mechanism · 3025 words

Neuroimmune Dysfunction in Frontotemporal Dementia

mechanism · 2778 words

C1QA Gene — Complement Component 1q A Chain

gene · 2340 words

Complement Dysregulation in CBS and 4R Tauopathies

mechanism · 2071 words

Microglial Dysfunction in Alzheimer's Disease

mechanism · 2063 words

Pathway Diagram

graph TD
    C1QB["<b>C1QB</b>"]
    Als{"Als"}
    C1QB -->|"activates"| Als
    Ms{"Ms"}
    C1QB -->|"activates"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    C1QB -->|"activates"| Amyotrophic_Lateral_Sclerosis
    Heart_Failure{"Heart Failure"}
    C1QB -->|"regulates"| Heart_Failure
    C1QB -->|"regulates"| Als
    Hepatitis{"Hepatitis"}
    C1QB -->|"regulates"| Hepatitis
    Cardiac{"Cardiac"}
    C1QB -->|"regulates"| Cardiac
    MET["MET"]
    C1QB -->|"interacts with"| MET
    C1Q["C1Q"]
    C1QB -->|"interacts with"| C1Q
    Complement(["Complement"])
    C1QB -->|"interacts with"| Complement
    Immune_Response(["Immune Response"])
    C1QB -->|"interacts with"| Immune_Response
    ASTROCYTES["ASTROCYTES"]
    C1QB -->|"activates"| ASTROCYTES
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"interacts with"| C1QB
    CTSH["CTSH"]
    CTSH -->|"interacts with"| C1QB
    CCR1["CCR1"]
    CCR1 -->|"regulates"| C1QB
    MRC1["MRC1"]
    MRC1 -->|"regulates"| C1QB
    style C1QB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (169)

TargetRelationTypeStr
Immune Cell Infiltrationassociated_withprocess0.80
complement cascadeparticipates_inpathway0.70
Alsactivatesdisease0.65
Msactivatesdisease0.65
Amyotrophic Lateral Sclerosisactivatesdisease0.65

Incoming (81)

SourceRelationTypeStr
CTSHinteracts_withgene0.60
CCR1regulatesgene0.60
MRC1regulatesgene0.60
APOEassociated_withgene0.60
KMT2Dassociated_withgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV I 0.497 neurodegeneration Are interneuron oscillation deficits com

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found