protein 647 words KG: C1QCPROTEIN 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

C1QC Protein

🔬 Protein Info
Gene SymbolC1QC
AliasesC1QCPROTEIN
FunctionThe C1QC gene encodes the C chain of the C1q protein, which is the recognition component of the classical complement pathway.
Primary Expressionvarious tissues, with high expression in:
Molecular Weight26 kDa
Amino Acids245 aa
PathwaysComplement
Ensembl IDENSG00000166922
GeneCardsC1QC
Human Protein AtlasC1QC
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
InteractionsC1Q, C1QA, CD14, CD163, CTSB, CTSL
KG Connections220 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Complement C1q Mimetic Decoy Therapy
Score: 0.48
Age-Dependent Complement C4b Upregulation Drives Synaptic Vu
Score: 0.47

Related Analyses (10)

What are the specific molecular mechanisms by which C1Q comp
neuroinflammation · failed
How does SPI1 transcriptionally regulate C1QA and C1QC expre
neuroinflammation · completed
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (13)

Gene expression validation in apoE-/- mice
validation · proposed · Score: 0.85
ox-LDL treatment of RAW264.7 macrophages
exploratory · proposed · Score: 0.85
Validation of hub genes in ox-LDL treated RAW264.7 macrophag
exploratory · proposed · Score: 0.80
Validation of hub genes in apoE-/- atherosclerotic mice
validation · proposed · Score: 0.80
scRNA-seq analysis of human atherosclerotic plaques
exploratory · proposed · Score: 0.90

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in