disease

multiple sclerosis

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about multiple sclerosis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2461Connections

0Hypotheses

1Analyses

41Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	STING1, IL-6, TNF-α, ALS, AQP4, APOE, GPR37, ALOX5
Therapeutic Agents	DMF, trehalose, statins, metformin, lecanemab, quercetin
KG Connections	260 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    multiple_sclerosis["multiple sclerosis"] -->|"affects"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    multiple_sclerosis["multiple sclerosis"] -->|"affects"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    multiple_sclerosis["multiple sclerosis"] -->|"affects"| oligodendrocytes["oligodendrocytes"]
    style oligodendrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    multiple_sclerosis["multiple sclerosis"] -->|"affects"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    multiple_sclerosis["multiple sclerosis"] -->|"affects"| spinal_cord["spinal cord"]
    style spinal_cord fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    multiple_sclerosis["multiple sclerosis"] -->|"affects"| white_matter["white matter"]
    style white_matter fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    multiple_sclerosis["multiple sclerosis"] -->|"involves"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    CLEC16A["CLEC16A"] -->|"therapeutic target"| multiple_sclerosis["multiple sclerosis"]
    style CLEC16A fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DMF["DMF"] -->|"treats"| multiple_sclerosis["multiple sclerosis"]
    style DMF fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| multiple_sclerosis["multiple sclerosis"]
    style ALS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    oligodendrocytes_1["oligodendrocytes"] -->|"associated"| multiple_sclerosis["multiple sclerosis"]
    style oligodendrocytes_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    STING["STING"] -->|"therapeutic target"| multiple_sclerosis["multiple sclerosis"]
    style STING fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style multiple_sclerosis fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (748)

Target	Relation	Type	Str
microglia	affects	cell_type	0.90
astrocytes	affects	cell_type	0.90
oligodendrocytes	affects	cell_type	0.90
neurons	affects	cell_type	0.90
spinal cord	affects	brain_region	0.90
white matter	affects	brain_region	0.90
oxidative stress response	involves	pathway	0.90
blood-brain barrier	involves	pathway	0.90
complement cascade	involves	pathway	0.80
unfolded protein response	involves	pathway	0.80
blood-brain barrier	affects	brain_region	0.80
T cells	affects	cell_type	0.80
axon	disrupts	organelle	0.80
neural stem cells	affects	cell_type	0.80
hippocampus	affects	brain_region	0.70
necroptosis	involves	pathway	0.70
ferroptosis	involves	pathway	0.70
cortex	affects	brain_region	0.70
apoptosis pathway	involves	pathway	0.70
cGAS-STING	involves	pathway	0.70
purinergic receptor	involves	receptor	0.70
endothelial cells	affects	cell_type	0.60
pyroptosis	involves	pathway	0.60
cerebellum	affects	brain_region	0.60
macrophages	affects	cell_type	0.60
lipid metabolism	involves	pathway	0.60
NF-kB signaling	involves	pathway	0.60
ubiquitin-proteasome	involves	pathway	0.60
mitochondrial function	involves	pathway	0.60
autophagy pathway	involves	pathway	0.60
temporal lobe	affects	brain_region	0.60
serotonin	disrupts	neurotransmitter	0.60
endosome	disrupts	organelle	0.60
interneurons	affects	cell_type	0.60
nicotinic receptor	involves	receptor	0.60
B cells	affects	cell_type	0.60
glutamate signaling	involves	pathway	0.60
synaptic plasticity	involves	pathway	0.60
JAK-STAT signaling	involves	pathway	0.60
glymphatic clearance	involves	pathway	0.60
TGF-beta signaling	involves	pathway	0.55

Incoming (1713)

Source	Relation	Type	Str
CLEC16A	therapeutic_target	gene	0.92
DMF	treats	drug	0.90
ALS	associated_with	gene	0.90
oligodendrocytes	associated_with	cell_type	0.90
STING	therapeutic_target	protein	0.88
MAPK	therapeutic_target	pathway	0.80
ERK	therapeutic_target	protein	0.80
AQP4	associated_with	gene	0.80
oligodendrocytes	activates	cell_type	0.80
astrocytes	activates	cell_type	0.80
oligodendrocytes	inhibits	cell_type	0.80
mitochondrial dysfunction	implicated_in	process	0.80
HMGCR	implicated_in	gene	0.80
SOLTNF	implicated_in	protein	0.80
MAPK	regulates	pathway	0.75
TNF-α	associated_with	protein	0.75
heavy metals	risk_factor_for	compound	0.75
STING1	associated_with	protein	0.70
HSV-1	associated_with	process	0.70
NRF2	protects_against	protein	0.70
IL-6	causes	protein	0.70
IL-6	associated_with	protein	0.70
neuronal damage	associated_with	process	0.70
trehalose	treats	drug	0.70
AQP4	activates	gene	0.70
STING	associated_with	gene	0.70
GFAP	associated_with	gene	0.70
ALS	treats	gene	0.70
microglia	associated_with	cell_type	0.70
oligodendrocytes	interacts_with	cell_type	0.70
oligodendrocytes	expressed_in	cell_type	0.70
oligodendrocytes	causes	cell_type	0.70
quercetin	treats	drug	0.70
APOE4	activates	gene	0.70
AQP4	interacts_with	gene	0.60
AQP4	treats	gene	0.60
APOE	associated_with	gene	0.60
GPR37	expressed_in	gene	0.60
GPR37	implicated_in	gene	0.60
ALOX5	implicated_in	gene	0.60
AQP1	associated_with	gene	0.60
AQP4	causes	gene	0.60
C3	inhibits	gene	0.60
CXCL10	associated_with	gene	0.60
C3	protects_against	gene	0.60
ALS	implicated_in	gene	0.60
RIPK3	treats	gene	0.60
RIPK1	treats	gene	0.60
AMPK	associated_with	gene	0.60
RNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.505

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

multiple sclerosis

Understanding Entity Pages

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Corticobasal Degeneration (CBD)

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

PD Cure Roadmap

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

CLCN10 — Chloride Voltage-Gated Channel 10

Oligodendrocytes

oxidative-stress-comparison

Blood-Brain Barrier Dysfunction in Neurodegeneration

amyloid-beta-metalloproteinases

TREM2 Microglial Signaling Pathway in Neurodegeneration

AI and Machine Learning in Neurodegeneration

Vitamin D Signaling Pathway in Neurodegeneration