FLOT1 Gene
Overview
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">FLOT1 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>FLOT1</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Flotillin 1</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>6p21.3</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>10211</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>606823</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000231768</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>O75955</td>
</tr>
<tr>
<td class="label">Brain Region</td>
<td>Expression Level</td>
</tr>
<tr>
<td class="label">[Hippocampus](/brain-regions/hippocampus)</td>
<td>Moderate-High</td>
</tr>
<tr>
<td class="label">Cerebral [Cortex](/brain-regions/cortex)</td>
<td>Moderate-High</td>
</tr>
<tr>
<td class="label">Cerebellum</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Basal Ganglia</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Brain Stem</td>
<td>Low-Moderate</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer's-disease" style="color:#ef9a9a">Alzheimer's disease</a>, <a href="/wiki/parkinson's-disease" style="color:#ef9a9a">Parkinson's disease</a>, <a href="/wiki/cancer" style="color:#ef9a9a">cancer</a>, <a href="/wiki/glioblastoma" style="color:#ef9a9a">glioblastoma</a>, <a href="/w
...FLOT1 Gene
Overview
<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">FLOT1 Gene</th>
</tr>
<tr>
<td class="label">Gene Symbol</td>
<td>FLOT1</td>
</tr>
<tr>
<td class="label">Full Name</td>
<td>Flotillin 1</td>
</tr>
<tr>
<td class="label">Chromosomal Location</td>
<td>6p21.3</td>
</tr>
<tr>
<td class="label">NCBI Gene ID</td>
<td>10211</td>
</tr>
<tr>
<td class="label">OMIM ID</td>
<td>606823</td>
</tr>
<tr>
<td class="label">Ensembl ID</td>
<td>ENSG00000231768</td>
</tr>
<tr>
<td class="label">UniProt ID</td>
<td>O75955</td>
</tr>
<tr>
<td class="label">Brain Region</td>
<td>Expression Level</td>
</tr>
<tr>
<td class="label">[Hippocampus](/brain-regions/hippocampus)</td>
<td>Moderate-High</td>
</tr>
<tr>
<td class="label">Cerebral [Cortex](/brain-regions/cortex)</td>
<td>Moderate-High</td>
</tr>
<tr>
<td class="label">Cerebellum</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Basal Ganglia</td>
<td>Moderate</td>
</tr>
<tr>
<td class="label">Brain Stem</td>
<td>Low-Moderate</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer's-disease" style="color:#ef9a9a">Alzheimer's disease</a>, <a href="/wiki/parkinson's-disease" style="color:#ef9a9a">Parkinson's disease</a>, <a href="/wiki/cancer" style="color:#ef9a9a">cancer</a>, <a href="/wiki/glioblastoma" style="color:#ef9a9a">glioblastoma</a>, <a href="/wiki/major-depressive-disorder" style="color:#ef9a9a">major depressive disorder</a></td>
</tr>
<tr>
<td class="label">SciDEX Hypotheses</td>
<td><a href="/hypothesis/h-a015e80e" style="color:#ce93d8" title="Score: 0.42">Flotillin-1 Stabilization Compounds...</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">50 edges</a></td>
</tr>
</table>
Flot1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Introduction
Flot1 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@zhou2020]
Gene Overview
FLOT1 (Flotillin 1) is a lipid raft-associated protein involved in cellular membrane organization, signal transduction, and neuroinflammation. It plays emerging roles in neurodegenerative disease pathogenesis. [@chen2021]
Protein Structure
FLOT1 is a ~47 kDa integral membrane protein:
- Phloretin-Binding Domain: Characteristic of flotillin proteins
- SPFH Domain: Membrane-scaffold protein family domain
- Tetratricopeptide Repeats: Protein-protein interaction motifs
- N-terminal and C-terminal Cytoplasmic Domains
FLOT1 forms hetero-oligomeric complexes in lipid rafts.
Normal Function
FLOT1 performs essential cellular functions:
Lipid Raft Organization: Essential for formation and maintenance of lipid rafts
Signal Transduction: Organizes signaling complexes at the plasma membrane
Membrane Trafficking: Regulates endocytosis and vesicle formation
Cell Adhesion: Mediates cell-cell adhesion through raft domains
Immune Response: Modulates immune cell activation and cytokine productionDisease Associations
Alzheimer's Disease
- Expression Changes: FLOT1 expression altered in AD brain
- [Aβ](/proteins/amyloid-beta) Interaction: FLOT1 localizes with amyloid plaques
- Neuroinflammation: Regulates microglial activation and neuroinflammation
- Therapeutic Potential: FLOT1 modulators may affect AD progression
Parkinson's Disease
- FLOT1 in Lewy bodies
- Associated with [α-synuclein](/proteins/alpha-synuclein) aggregation
- Modulates microglial response in PD
Other Neurological Conditions
- Multiple Sclerosis: FLOT1 affects immune cell trafficking
- Brain Ischemia: Regulates inflammatory response to stroke
- Traumatic Brain Injury: Involved in secondary injury mechanisms
Expression Patterns
FLOT1 is expressed in:
- [Neurons](/entities/neurons)
- [Astrocytes](/entities/astrocytes)
- [Microglia](/cell-types/microglia-neuroinflammation) (highly expressed in activated microglia)
- [Oligodendrocytes](/cell-types/oligodendrocytes) Vascular endothelial cells
Therapeutic Implications
Therapeutic Strategies
FLOT1 Modulators: Small molecules to regulate FLOT1 function
Anti-inflammatory Targeting: FLOT1 as target to reduce neuroinflammation
Lipid Raft Disruptors: Target lipid raft integrity to affect signaling
Microglial Modulation: Target FLOT1 in microgliaClinical Development
- No FLOT1-targeted therapies in clinical trials
- Biomarker potential: FLOT1 in CSF may reflect neuroinflammation
- Research tool: FLOT1 as marker for lipid rafts
Overview
Flot1 Gene plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Background
The study of Flot1 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Brain Atlas Resources
- [Allen Human Brain Atlas - Gene Expression](https://human.brain-map.org/microarray/search/show?search_term=FLOT1) - View FLOT1 expression data in the human brain
- [Allen Brain Atlas API](https://api.brain-map.org/) - Programmatic access to brain atlas data
- [BrainSpan Atlas of the Developing Human Brain](https://brainspan.org/) - Developmental expression data for FLOT1
See Also
- [Neuroinflammation](/mechanisms/neuroinflammation-pathway)
- [Alzheimer's Disease](/diseases/alzheimers-disease)
- [Parkinson's Disease](/diseases/parkinsons-disease)
- [Microglia in Neurodegeneration](/cell-types/microglia)
- Lipid Raft Signaling
From the [SciDEX Exchange](/exchange) — scored by multi-agent debate
- [Flotillin-1 Stabilization Compounds](/hypothesis/h-a015e80e) — <span style="color:#ffd54f;font-weight:600">0.42</span> · Target: FLOT1
Pathway Context
Mermaid diagram (expand to render)
Pathway Diagram
The following diagram shows the key molecular relationships involving FLOT1 Gene discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)