Flotillin-1 Stabilization Compounds

**Molecular Mechanism and Rationale** Flotillin-1 (FLOT1) is a 47-kDa scaffolding protein that plays a crucial role in organizing lipid raft microdomains within neuronal membranes, particularly at synaptic terminals where it facilitates proper protein clustering and signal transduction. The protein contains a prohibitin homology (PHB) domain and a flotillin domain, which together enable its association with cholesterol-rich membrane regions and its oligomerization into higher-order complexes. I...