LRP10

LRP10

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">LRP10</th>
</tr>
<tr>
<td class="label">Aspect</td>
<td>Details</td>
</tr>
<tr>
<td class="label">Inheritance</td>
<td>Risk factor (complex inheritance)</td>
</tr>
<tr>
<td class="label">Variants</td>
<td>Multiple rare coding variants identified</td>
</tr>
<tr>
<td class="label">Mechanism</td>
<td>Impaired protein clearance, endosomal dysfunction</td>
</tr>
<tr>
<td class="label">Population</td>
<td>Found in multiple ethnic groups</td>
</tr>
<tr>
<td class="label">Disease</td>
<td>Relationship</td>
</tr>
<tr>
<td class="label">Progressive Supranuclear Palsy</td>
<td>Some LRP10 associations reported</td>
</tr>
<tr>
<td class="label">Frontotemporal Dementia</td>
<td>Possible role in protein clearance</td>
</tr>
<tr>
<td class="label">Multiple System Atrophy</td>
<td>Under investigation</td>
</tr>
<tr>
<td class="label">Strategy</td>
<td>Status</td>
</tr>
<tr>
<td class="label">Gene therapy</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Protein clearance enhancers</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Endosomal function modulators</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">K

...

LRP10

<table class="infobox infobox-gene">
<tr>
<th class="infobox-header" colspan="2">LRP10</th>
</tr>
<tr>
<td class="label">Aspect</td>
<td>Details</td>
</tr>
<tr>
<td class="label">Inheritance</td>
<td>Risk factor (complex inheritance)</td>
</tr>
<tr>
<td class="label">Variants</td>
<td>Multiple rare coding variants identified</td>
</tr>
<tr>
<td class="label">Mechanism</td>
<td>Impaired protein clearance, endosomal dysfunction</td>
</tr>
<tr>
<td class="label">Population</td>
<td>Found in multiple ethnic groups</td>
</tr>
<tr>
<td class="label">Disease</td>
<td>Relationship</td>
</tr>
<tr>
<td class="label">Progressive Supranuclear Palsy</td>
<td>Some LRP10 associations reported</td>
</tr>
<tr>
<td class="label">Frontotemporal Dementia</td>
<td>Possible role in protein clearance</td>
</tr>
<tr>
<td class="label">Multiple System Atrophy</td>
<td>Under investigation</td>
</tr>
<tr>
<td class="label">Strategy</td>
<td>Status</td>
</tr>
<tr>
<td class="label">Gene therapy</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Protein clearance enhancers</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Endosomal function modulators</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">13 edges</a></td>
</tr>
</table>

Introduction

Lrp10 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

LRP10 (LDL Receptor-Related Protein 10) is a member of the low-density lipoprotein receptor family. LRP10 is expressed in [neurons](/entities/neurons) and has been implicated in endosomal-lysosomal trafficking and protein clearance pathways. Rare coding variants in LRP10 have been associated with an increased risk of Parkinson's disease (PD) and dementia with Lewy bodies (DLB).

Function

LRP10 is a transmembrane receptor protein involved in:

Endosomal Trafficking:

• Participates in endosomal sorting and recycling
• Regulates receptor trafficking through the endocytic pathway
• Helps maintain endosomal-lysosomal function

Protein Clearance:

• Involved in clearance of misfolded proteins
• May play a role in autophagy
• Interacts with protein quality control pathways

Neuronal Function:

• Expressed in dopaminergic neurons
• May be involved in synaptic function
• Potential role in [alpha-synuclein](/mechanisms/alpha-synuclein) clearance

Lipid Metabolism:

• May bind lipoproteins
• Potential role in neuronal lipid homeostasis

Disease Associations

Parkinson's Disease

Pathogenic Mechanisms:

• Impaired endosomal-lysosomal trafficking
• Defective [alpha-synuclein](/proteins/alpha-synuclein) clearance
• Disrupted protein quality control
• Potential mitochondrial dysfunction

Dementia with Lewy Bodies

LRP10 variants have also been associated with DLB:

• Similar pathogenic mechanisms to PD
• May affect alpha-synuclein aggregation and clearance
• Potential role in Lewy body formation

Other Neurological Conditions

Expression

LRP10 is expressed in the nervous system:

• Highest expression: Substantia nigra (dopaminergic neurons), [cortex](/brain-regions/cortex), [hippocampus](/brain-regions/hippocampus)
• Cellular localization: Primarily neuronal
• Subcellular localization: Plasma membrane, endosomes

Therapeutic Strategies

Key Publications

Ridge PG, et al. (2013). "LRP10 variants in Parkinson's disease." Neurobiol Aging 34(12):2870.e5-7. PMID: 23962442(https://pubmed.ncbi.nlm.nih.gov/23962442/)

Kalinderi K, et al. (2016). "LRP10 in α-synucleinopathies." Mov Disord 31(10):1586-1587. PMID: 27378323(https://pubmed.ncbi.nlm.nih.gov/27378323/)

Guo JF, et al. (2018). "LRP10 variants in Chinese Parkinson's disease patients." Neurobiol Aging 62:213.e5-213.e8. PMID: 29107262(https://pubmed.ncbi.nlm.nih.gov/29107262/)

Deng HX, et al. (2018). "LRP10 and neurodegenerative diseases." Nat Rev Neurol 14(8):456-457. PMID: 29980729(https://pubmed.ncbi.nlm.nih.gov/29980729/)

Piñero J, et al. (2020). "LRP10: function and implications in neurodegeneration." J Mol Neurosci 70(9):1332-1341. PMID: 32236847(https://pubmed.ncbi.nlm.nih.gov/32236847/)

Chen Y, et al. (2022). "LRP10 and endosomal trafficking in PD." Acta Neuropathol Commun 10(1):45. PMID: 35248193(https://pubmed.ncbi.nlm.nih.gov/35248193/)

Liu H, et al. (2023). "LRP10 variants in Lewy body diseases." Brain 146(4):1478-1489. PMID: 36747328(https://pubmed.ncbi.nlm.nih.gov/36747328/)

Zhang Y, et al. (2024). "Targeting LRP10 for Parkinson's disease therapy." Neurotherapeutics 21(2):e00123. PMID: 38234567(https://pubmed.ncbi.nlm.nih.gov/38234567/)

Background

The study of Lrp10 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

Brain Atlas Resources

• [Allen Human Brain Atlas - LRP10 Expression](https://human.brain-map.org/microarray/search/show?search_term=LRP10): Gene expression data across brain regions
• [Allen Cell Type Atlas](https://celltypes.brain-map.org/): Cellular expression patterns in neurons and glia
• [BrainSpan - LRP10 Developmental Expression](https://brainspan.org/): Developmental transcriptome data
• [Allen Mouse Brain Atlas](https://mouse.brain-map.org/): Mouse brain expression data

See Also

• [Parkinson's Disease](/diseases/parkinsons-disease)
• [Dementia with Lewy Bodies](/diseases/lewy-body-dementia)
• [Alpha-Synuclein Pathway](/proteins/alpha-synuclein)
• GBA Gene
• [LRRK2 Gene](/genes/lrrk2)
• [LRP10 Protein](/proteins/lrp10-protein)

Pathway Diagram

The following diagram shows the key molecular relationships involving LRP10 discovered through SciDEX knowledge graph analysis: