🧫
Tau Propagation Causality Test — Does Tau Spread Drive Neurodegeneration or Is It a Bystander?
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-tau-prop
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.900126Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['ADRA2A/HSP90AA1/LRP1'], 'diseases': ['Neurodegeneration']} |
| model_system | human |
| summary | # Tau Propagation Causality Test — Does Tau Spread Drive Neurodegeneration or Is It a Bystander? ## Background and Rationale Tau protein aggregation and spread is a hallmark of Alzheimer's disease and |
| replication_status | single_study |
| methodology_notes | Phase 1 (Months 0-3): Recruit 150 participants across cognitive spectrum: 50 cognitively normal elderly, 50 mild cognitive impairment, 50 mild AD dementia. Baseline assessments include tau-PET ([18F]M |
| primary_outcome | Validate Tau Propagation Causality Test — Does Tau Spread Drive Neurodegeneration or Is It a Bystander? |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.900130'} |
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