🧫
Anti-Tau Immunotherapy Dosing Optimization
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-anti-tau
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.907277Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['ADRA2A/HSP90AA1/LRP1'], 'diseases': ["Alzheimer's Disease"]} |
| model_system | human |
| summary | # Anti-Tau Immunotherapy Dosing Optimization ## Background and Rationale This clinical optimization study focuses on establishing optimal dosing regimens for tau-targeting immunotherapies in Alzheimer |
| replication_status | single_study |
| methodology_notes | **Phase 1: Patient Recruitment and Screening (Months 1-3)** • Recruit 240 patients with mild-to-moderate Alzheimer's disease (MMSE 14-26, CDR 0.5-2.0) • Conduct comprehensive screening including tau-P |
| primary_outcome | Dose-dependent reduction in tau-PET signal measured by longitudinal [18F]MK-6240 or [18F]PI-2620 PET imaging at 12 months compared to baseline. |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.907284'} |
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