gene

LRP10

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections
0Hypotheses
0Analyses
26Outgoing
5Incoming

Summary

LRP10 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, inhibits. Associated with Alzheimer, Ms. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolLRP10
Protein TypeReceptor
FunctionLRP10 is a transmembrane receptor protein involved in
Primary Expressionneurons and has been implicated in endosomal-lysosomal trafficking and protein clearance pathways
GeneCardsLRP10
Human Protein AtlasLRP10
AspectDetails
InheritanceRisk factor (complex inheritance)
VariantsMultiple rare coding variants identified
MechanismImpaired protein clearance, endosomal dysfunction
PopulationFound in multiple ethnic groups
DiseaseRelationship
Progressive Supranuclear PalsySome LRP10 associations reported
Frontotemporal DementiaPossible role in protein clearance
Multiple System AtrophyUnder investigation
Associated DiseasesParkinson's disease
InteractionsAPP, SORL1, ALZHEIMER'S DISEASE, ENDOSOMES
KG Connections31 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

LRP10

gene · 624 words

DNAJC13 — DnaJ Heat Shock Protein Family Member C13

gene · 3528 words

LRP10 Protein

protein · 644 words

Proteins

index · 296 words

Genes

index · 271 words

Pathway Diagram

graph TD
    LRP10["<b>LRP10</b>"]
    TREM2["TREM2"]
    LRP10 -->|"associated with"| TREM2
    LRP10 -->|"expressed in"| TREM2
    Alzheimer{"Alzheimer"}
    LRP10 -->|"expressed in"| Alzheimer
    Ms{"Ms"}
    LRP10 -->|"expressed in"| Ms
    LRP10 -->|"inhibits"| Alzheimer
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    LRP10 -->|"inhibits"| ALZHEIMER_S_DISEASE
    LDLR["LDLR"]
    LRP10 -->|"associated with"| LDLR
    APP["APP"]
    LRP10 -->|"activates"| APP
    ENDOSOMES["ENDOSOMES"]
    LRP10 -->|"activates"| ENDOSOMES
    neurodegeneration["neurodegeneration"]
    LRP10 -->|"implicated in"| neurodegeneration
    ALZHEIMER_S_DISEASE -->|"expressed in"| LRP10
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"expressed in"| LRP10
    APOE["APOE"]
    APOE -->|"associated with"| LRP10
    style LRP10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (26)

TargetRelationTypeStr
TREM2associated_withgene0.80
TREM2expressed_ingene0.70
Alzheimerexpressed_indisease0.65
Msexpressed_indisease0.65
Alzheimerinhibitsdisease0.65

Incoming (5)

SourceRelationTypeStr
APOEassociated_withgene0.60
APOEexpressed_ingene0.60
ALZHEIMER'S DISEASEexpressed_ingene0.60
MICROGLIAexpressed_ingene0.60
ALZHEIMERexpressed_ingene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found