Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LRP10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
LRP10 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, associated with, inhibits. Associated with Alzheimer, Ms. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | LRP10 |
| Protein Type | Receptor |
| Function | LRP10 is a transmembrane receptor protein involved in |
| Primary Expression | neurons and has been implicated in endosomal-lysosomal trafficking and protein clearance pathways |
| GeneCards | LRP10 |
| Human Protein Atlas | LRP10 |
| Aspect | Details |
| Inheritance | Risk factor (complex inheritance) |
| Variants | Multiple rare coding variants identified |
| Mechanism | Impaired protein clearance, endosomal dysfunction |
| Population | Found in multiple ethnic groups |
| Disease | Relationship |
| Progressive Supranuclear Palsy | Some LRP10 associations reported |
| Frontotemporal Dementia | Possible role in protein clearance |
| Multiple System Atrophy | Under investigation |
| Associated Diseases | Parkinson's disease |
| Interactions | APP, SORL1, ALZHEIMER'S DISEASE, ENDOSOMES |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LRP10["<b>LRP10</b>"]
TREM2["TREM2"]
LRP10 -->|"associated with"| TREM2
LRP10 -->|"expressed in"| TREM2
Alzheimer{"Alzheimer"}
LRP10 -->|"expressed in"| Alzheimer
Ms{"Ms"}
LRP10 -->|"expressed in"| Ms
LRP10 -->|"inhibits"| Alzheimer
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
LRP10 -->|"inhibits"| ALZHEIMER_S_DISEASE
LDLR["LDLR"]
LRP10 -->|"associated with"| LDLR
APP["APP"]
LRP10 -->|"activates"| APP
ENDOSOMES["ENDOSOMES"]
LRP10 -->|"activates"| ENDOSOMES
neurodegeneration["neurodegeneration"]
LRP10 -->|"implicated in"| neurodegeneration
ALZHEIMER_S_DISEASE -->|"expressed in"| LRP10
MICROGLIA["MICROGLIA"]
MICROGLIA -->|"expressed in"| LRP10
APOE["APOE"]
APOE -->|"associated with"| LRP10
style LRP10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| TREM2 | associated_with | gene | 0.80 |
| TREM2 | expressed_in | gene | 0.70 |
| Alzheimer | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| LDLR | associated_with | gene | 0.60 |
| APP | activates | gene | 0.60 |
| APOE | expressed_in | gene | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| SORL1 | interacts_with | gene | 0.60 |
| SORL1 | regulates | gene | 0.60 |
| neurodegeneration | translocates_to | disease | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| ENDOSOMES | activates | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| App | expressed_in | protein | 0.60 |
| Parkinson's disease | interacts_with | disease | 0.60 |
| ALS | expressed_in | disease | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| Parkinson's disease | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | associated_with | gene | 0.60 |
| APOE | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| MICROGLIA | expressed_in | gene | 0.60 |
| ALZHEIMER | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||