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NIH Drug Repurposing Program for Neurodegenerative Diseases

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entity_type	institution
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Linked Artifacts (54)

mentions🧫Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Tr70%

mentions🧫Cognitive Reserve Mechanisms in Alzheimer's Disease — M70%

related🧫ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De70%

related🧫Circadian-Vascular-Metabolic Syndrome (CVMS) Intervention Tr63%

related🧫Cognitive Reserve Mechanisms in Alzheimer's Disease — M63%

mentions🧪Adenosine-Astrocyte Metabolic Reset55%

mentions🧪Microglial Purinergic Reprogramming55%

mentions🧪Circadian Glymphatic Entrainment via Targeted Orexin Recepto55%

mentions🧪Aquaporin-4 Polarization Rescue55%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy55%

mentions🧪Sphingomyelin Synthase Activators for Raft Remodeling55%

mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna50%

mentions🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%

mentions🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling50%

mentions🧪TREM2-Dependent Microglial Senescence Transition50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

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related🔬Is disrupted sleep a cause or consequence of neurodegenerati50%

related🔬What gene expression changes in the aging mouse brain predic50%

related🔬How does metabolic reprogramming (glucose metabolism shifts,50%

related🧪APOE-Dependent Autophagy Restoration50%

related🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%

related🧪APOE-TREM2 Interaction Modulation50%

related🧪TREM2-Mediated Selective Aggregate Clearance Pathway50%

related🔬What are the mechanisms underlying mechanistic role of apoe 50%

mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa40%

mentions🔬What are the mechanisms underlying protein aggregation cross40%

mentions🔬Is disrupted sleep a cause or consequence of neurodegenerati40%

mentions🔬What gene expression changes in the aging mouse brain predic40%

mentions🔬How does metabolic reprogramming (glucose metabolism shifts,40%

related🔬What are the mechanisms underlying 4r-tau strain-specific sp38%

related🔬What are the mechanisms underlying what are the mechanisms b38%

related🔬Investigate how lipid raft composition (cholesterol metaboli38%

related🔬What are the mechanisms underlying sleep disruption as cause38%

related🔬What are the mechanisms underlying perivascular spaces and g38%

related🔬What gene expression changes in the aging mouse brain predic38%