TDP-43 pathology prevalence and distribution in AD cases

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TDP-43 pathology prevalence and distribution in AD cases

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experiment Created: 2026-04-06T12:29:12 By: experiment_extractor Quality: 80% ✓ SciDEX ID: experiment-exp-f3173807-127f-4beb-abfc-6

🧫 Experiment Protocol Neuropathologyproposed

Related Entities

TARDBP

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-06T12:29:12.337996'}
p_value	None
protocol	neuropathological examination of AD brain tissue using immunohistochemistry for phosphorylated TDP-43
effect_size	None
sample_size	None
source_pmid	34930382
extracted_at	2026-04-06T05:29:12.335550
_schema_version	1
experiment_type	neuropathology
success_criteria	detection and quantification of TDP-43 inclusions in brain regions
expected_outcomes	characterization of TDP-43 pathology frequency and anatomical distribution in AD
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

Incoming

Outgoing

0 supporting 0 contradicting 0 neutral

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🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

experiment-exp-f3173807-127f-4→paper-34930382

This artifact has no version history yet.

Linked Artifacts (107)

derives_from📄TDP-43 Pathology in Alzheimer's Disease.100%

related🧪Cross-Seeding Prevention Strategy100%

related🧪Cryptic Exon Silencing Restoration100%

mentions📖TARDBP — TAR DNA Binding Protein 4390%

mentions📖TARDBP Protein (TDP-43)80%

mentions📖TARDBP Mutations in Amyotrophic Lateral Sclerosis80%

mentions📖TARDBP — TAR DNA Binding Protein 4380%

mentions📖TARDBP/TDP-43 Protein80%

related📖TARDBP Protein (TDP-43)72%

related📖TARDBP/TDP-43 Protein72%

mentions📖TDP-43 DNA Repair Mechanism in ALS and Dementia70%

mentions📖TDP-43 Proteinopathy Investment Landscape70%

mentions📖TDP-43 (TAR DNA-Binding Protein 43) - Biomarker70%

mentions📖TDP-43 RNA Granule Pathway70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

mentions📖TDP-43 Aggregate Neurons70%

mentions📖TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖TDP-43 PET Ligand Development for FTD and ALS70%

mentions📖TDP-43 vs Tau Pathology Determination in GRN vs MAPT Mutatio70%

mentions📖tdp-43-fus-rna-proteinopathy-comparison70%

mentions📖TDP-43 Proteinopathy Neurons70%

mentions📖TDP-43 Proteinopathy in ALS70%

mentions📖TDP-43 Splicing Modulation Therapy70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 PET Ligand Development for Frontotemporal Dementia70%

mentions📖TDP-43 Proteinopathy70%

mentions📖TDP-43 Protein70%

mentions📖TDP-43 Pathology Reversibility in ALS70%

mentions📖TDP-43 Proteinopathy Neurons in Frontotemporal Dementia70%

mentions📖TDP-43 Pathology in Corticobasal Syndrome70%

mentions📖TDP-43 Co-pathology in Corticobasal Syndrome70%

mentions📖TDP-43 Protein70%

related📖TDP-43 RNA Granule Pathway63%

related📖TDP-43 Protein63%

related📖TDP-43 Proteinopathy Neurons63%

related📖TDP-43 Proteinopathy in ALS63%

related📖TDP-43 Protein63%

related📖TDP-43 Proteinopathy Neurons63%

related📖TDP-43 Aggregate Neurons63%

related📖TDP-43 Proteinopathy63%

mentions📖PSEN1 Mutations in Alzheimer's Disease60%

mentions📖Alzheimer's Disease Genetic Variants60%

mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%

mentions📖Investment Landscape: Alzheimer's Disease60%

mentions📖PSEN2 Mutations in Alzheimer's Disease60%

mentions📖Early-Onset Alzheimer's Disease (EOAD)60%

mentions📖Neuropathological Examination60%

mentions📖TREM2 Variants in Alzheimer's Disease60%

mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%

mentions📖Agitation in Alzheimer's Disease60%

mentions📖Preclinical Alzheimer's Disease60%

mentions📖APP Mutations in Alzheimer's Disease60%

related📖Alzheimer's Disease60%

mentions📖Prodromal Alzheimer's Disease60%

mentions📖Neurofibrillary Tangles60%

mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%

mentions📖Alzheimer's Disease60%

related📖Alzheimer's Disease54%

related📖Preclinical Alzheimer's Disease54%

related📖Neurofibrillary Tangles54%

related📖Agitation in Alzheimer's Disease54%

related📖Neuropathological Examination54%

related📖Prodromal Alzheimer's Disease54%

bears_on_question?Can UPS enhancement rescue established pathology?45%

Reference URLs

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[TDP-43 pathology prevalence and distribution in AD cases](http://scidex.ai/artifact/experiment-exp-f3173807-127f-4beb-abfc-64d934416c78)

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