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How do other PD genes (LRRK2, GBA, SNCA) interact with the DJ-1-PTEN-P53 network?
active
open question
Created: 2026-04-25T20:29:38
By: backfill_open_questions
Quality:
50%
✓ SciDEX
ID: open_question-f6631d41-1e4d-4bc5-9fad-d3
Open Question
open
Wiki: mechanisms-dj1-pten-p53-network
How do other PD genes (LRRK2, GBA, SNCA) interact with the DJ-1-PTEN-P53 network?
Importance Elo
1500
Field Rank
Rank #1172 in mechanisms
Tractability
0.50
Potential Impact
0.50
Evidence Summary
Extracted from wiki page mechanisms-dj1-pten-p53-network
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Evidence Bearing On This Question
Long-term perampanel treatment in A53T BAC-SNCA mice with PFF injection
discriminating experiment · experiment · 65%
Synthetic Biology Rewiring via Orthogonal Receptors
candidate answer · hypothesis · 65%
AAV Serotype Comparison for LRRK2 Knockdown in PD
discriminating experiment · experiment · 65%
AAV-LRRK2 Gene Therapy IND-Enabling Study Design
discriminating experiment · experiment · 60%
Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown
discriminating experiment · experiment · 60%
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develop PD
partial answer for · experiment · 55%
Transcriptional Autophagy-Lysosome Coupling
partial answer for · hypothesis · 55%
PTEC-specific RUBCN knockout mice phenotype analysis
discriminating experiment · experiment · 55%
Subcellular protein interaction role identification
partial answer for · experiment · 50%
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
bears on question · hypothesis · 50%
TFAM overexpression creates mitochondrial donor-recipient gradients for directed organelle trafficking
bears on question · hypothesis · 50%
TREM2-Mediated Selective Aggregate Clearance Pathway
bears on question · hypothesis · 50%
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
bears on question · hypothesis · 45%
Low Complexity Domain Cross-Linking Inhibition
partial answer for · hypothesis · 45%
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
bears on question · hypothesis · 40%
Pairwise Tournament History
No pairwise judgments recorded yet.
Derived Hypotheses And Proposals
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption
hypothesis | bears_on_question
TREM2-Mediated Selective Aggregate Clearance Pathway
hypothesis | bears_on_question
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
hypothesis | bears_on_question
Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
hypothesis | bears_on_question
DNMT1-Targeting Antisense Oligonucleotide Reset
hypothesis | bears_on_question
TFAM overexpression creates mitochondrial donor-recipient gradients for directed organelle trafficking
hypothesis | bears_on_question
Synthetic Biology Rewiring via Orthogonal Receptors
hypothesis | candidate_answer
Low Complexity Domain Cross-Linking Inhibition
hypothesis | partial_answer_for
Transcriptional Autophagy-Lysosome Coupling
hypothesis | partial_answer_for
Related Entities
▸Metadata
| status | open |
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-26T03:29:38.385694'} |
| field_tag | mechanisms |
| source_id | mechanisms-dj1-pten-p53-network |
| sub_field | dj1-pten-p53-network |
| source_kind | wiki |
| question_hash | ff5b56ac05d0a996a80f630c59931d6c359bf14770d493aa1f5b14566f4836a4 |
| question_text | How do other PD genes (LRRK2, GBA, SNCA) interact with the DJ-1-PTEN-P53 network? |
| importance_elo | 1500 |
| _schema_version | 1 |
| evidence_summary | Extracted from wiki page mechanisms-dj1-pten-p53-network |
| evidence_xref_at | 2026-04-27T12:47:55.171321+00:00 |
| tractability_score | 0.5 |
| potential_impact_score | 0.5 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
19
0 supporting
0 contradicting
0 neutral
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