DNMT1-Targeting Antisense Oligonucleotide Reset

**Molecular Mechanism and Rationale** DNA methyltransferase 1 (DNMT1) serves as the primary maintenance methyltransferase in mammalian cells, responsible for preserving DNA methylation patterns during cell division by adding methyl groups to hemimethylated CpG dinucleotides. In the context of neurodegeneration, DNMT1 dysregulation leads to aberrant hypermethylation of critical neuronal genes, particularly at promoter regions containing CpG islands. This pathological methylation silences neuropr...