Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption

graph TD
    A["PHB2 on Mitochondrial Inner Membrane"] --> B["Scaffolding/Structural Role"]
    B --> C["Cristae Organization"]
    B --> D["Mitophagy Receptor Function"]

    E["Tau"] --> F["Binds PHB2 on Mito Surface"]
    G["alpha-Synuclein"] --> F
    H["TDP-43"] --> F

    F --> I["PHB2 as Convergent Cross-Seeding Hub"]
    I --> J["Conformational Templating"]
    J --> K["Heterologous Protein Aggregation"]
    K --> L["Multi-Protein Toxic Complexes"]

    L --> M["Mitochondrial Membrane Disruption"]
    M --> N["Bioenergetic Collapse"]
    N --> O["Neurodegeneration"]

    P["PHB2 Modulator Therapy"] --> Q["Disrupt PHB2-Aggregate Interaction"]
    Q --> R["Block Cross-Seeding Platform"]
    R --> S["Prevent Multi-Protein Aggregation"]

    Q --> T["Preserve PHB2 Scaffolding Function"]
    T --> U["Maintained Cristae Integrity"]

    S --> V["Neuroprotection"]
    U --> V

    style A fill:#264653,stroke:#ffd54f,color:#e0e0e0
    style I fill:#3a1a1a,stroke:#ef9a9a,color:#e0e0e0
    style P fill:#1a3a4a,stroke:#4fc3f7,color:#e0e0e0
    style V fill:#2a3a1a,stroke:#c5e1a5,color:#e0e0e0