Systems Pharmacology and Experimental Validation of BuYang HuanWu Decoction in Vertebral Artery Stenosis: Targeting the AGE-RAGE/NF-κB Axis for Endothelial Protection and Plaque Stabilization.

ETHNOPHARMACOLOGICAL RELEVANCE: BuYang HuanWu Decoction (BYHW), a classical herbal formula first documented in Yilin Gaicuo (1830), is officially listed in the Chinese Pharmacopoeia for the treatment of stroke and sequelae attributed to "qi deficiency and blood stasis." Vertebral artery stenosis (VAS) is a leading cause of posterior circulation ischemic stroke-a condition for which BYHW has been traditionally prescribed. However, the molecular mechanism underlying its therapeutic effects against...