protein

ABCA1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ABCA1 (ATP-binding cassette transporter A1) is a member of the ABC transporter family that plays a critical role in cholesterol efflux and lipid homeostasis throughout the body, including the central nervous system[@vasiliou2009].

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🔬 Protein Info

Gene Symbol	ABCA1PROTEIN
Full Name	abca1-protein
Protein Type	Protein
Target Class	Transporter
Function	is a member of the ABC transporter family that plays a critical role in cholesterol efflux and lipid homeostasis throughout the body, including the central nervous system[@vasiliou2009].
Mechanism of Action	Small molecule modulators to enhance cholesterol efflux and HDL formation
Primary Expression	many tissues, including liver, macrophages, microglia, astrocytes, and neurons
Druggability	Medium (0.47)
Clinical Stage	Approved
UniProt ID	Search UniProt
GeneCards	ABCA1PROTEIN
Human Protein Atlas	ABCA1PROTEIN
Two transmembrane domains (TMDs)	Each containing 6 transmembrane helices
Extracellular loops	Form the substrate entry portal for lipids
Intracellular loops	Connect TMDs and contain regulatory elements
Associated Diseases	Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	25-Hydroxycholesterol, CS-6253, dexamethasone, quercetin, statins
Interactions	4E-BP1, abca2, ABCA2, ABCA4, ABCA7, ABCG1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HDL/apoE Particle Remodeling as a Therapeutic Swit APOE4 hypolipidation and ABCA1 mistrafficking impa ABCA1 Upregulation via LXRβ Agonism to Enhance Cho (+1 more)
KG Connections	1179 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ABCA1PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

abca1-protein

protein · 1305 words

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Pathway Diagram

graph TD
    ABCA1PROTEIN["ABCA1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ABCA1PROTEIN -->|"implicated_in"| neurodegeneration
    style ABCA1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ABCA1PROTEIN in their description or question text

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