protein

ABCA1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ABCA1 (ATP-binding cassette transporter A1) is a member of the ABC transporter family that plays a critical role in cholesterol efflux and lipid homeostasis throughout the body, including the central nervous system[@vasiliou2009].

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🔬 Protein Info

Gene Symbol	ABCA1
Full Name	abca1-protein
Chromosome	9q31.1
Protein Type	Transporter
Target Class	Transporter
Function	is a full-size ABC transporter with a classic architecture
Mechanism of Action	Small molecule modulators to enhance cholesterol efflux and HDL formation
Primary Expression	Brain (astrocytes, microglia, neurons), liver, macrophages, intestine
Druggability	Medium (0.47)
Clinical Stage	Approved
Molecular Weight	~270 kDa
Amino Acids	2,461 amino acids
Exons	50
Pathways	Cholesterol, Epigenetic, Lipid Metabolism, Microrna, Mitochondrial Function
UniProt ID	O95477
NCBI Gene ID	19
Ensembl ID	ENSG00000165029
GeneCards	ABCA1
Human Protein Atlas	ABCA1
Associated Diseases	AD, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMI, ARM
Known Drugs/Compounds	25-Hydroxycholesterol, statins, dexamethasone, quercetin
Interactions	LDLR, SREBF2, APOE, LOX, ABCG1, P2RY12
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	HDL/apoE Particle Remodeling as a Therapeutic Swit
KG Connections	1134 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ABCA1PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

abca1-protein

protein · 1305 words

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Pathway Diagram

graph TD
    ABCA1PROTEIN["ABCA1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ABCA1PROTEIN -->|"implicated_in"| neurodegeneration
    style ABCA1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found