Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about statins: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| LDLR | activates | protein | 0.90 |
| HMGCR | inhibits | gene | 0.90 |
| HMGCR | activates | gene | 0.80 |
| autophagy | regulates | process | 0.70 |
| LAMP2 | inhibits | protein | 0.70 |
| MMP9 | inhibits | protein | 0.70 |
| LDL | activates | gene | 0.70 |
| Alzheimer's disease | treats | disease | 0.70 |
| unfolded protein response | modulates | pathway | 0.70 |
| ABCA1 | activates | gene | 0.60 |
| P2RY12 | activates | gene | 0.60 |
| LOX | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| ACTB | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| AMPK signaling | modulates | pathway | 0.60 |
| ABCA1 | interacts_with | gene | 0.60 |
| P2RY12 | interacts_with | gene | 0.60 |
| LOX | interacts_with | gene | 0.60 |
| ULK1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| GPX4 | activates | gene | 0.60 |
| ferroptosis | modulates | pathway | 0.60 |
| GPX4 | inhibits | gene | 0.60 |
| SLC16A1 | interacts_with | gene | 0.60 |
| SLC16A1 | transported_by | gene | 0.60 |
| SLC16A1 | expressed_in | gene | 0.60 |
| SLC16A1 | inhibits | gene | 0.60 |
| HMGCR | treats | gene | 0.60 |
| APP | expressed_in | gene | 0.60 |
| APP | modulates | gene | 0.60 |
| HMGCR | regulates | gene | 0.60 |
| HMGCR | expressed_in | gene | 0.60 |
| HMGCR | modulates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| BDNF | treats | gene | 0.60 |
| neurodegeneration | treats | disease | 0.60 |
| stroke | treats | disease | 0.60 |
| glutamate signaling | modulates | pathway | 0.60 |
| HMGCR | protects_against | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| MAP1LC3 | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| ALS | treats | disease | 0.60 |
| ATP | interacts_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||