gene

ABCG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

253Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

3Debates

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🧬 Gene Info

Gene Symbol	ABCG1
Full Name	ATP-Binding Cassette Subfamily G Member 1
Chromosome	21q22.3
Protein Type	Transporter
Function	is a critical lipid transporter protein that plays a fundamental role in cellular cholesterol and phospholipid homeostasis.
Primary Expression	neurons, astrocytes, microglia, and oligodendrocytes, where it regulates brain lipid homeostasis and protects against neurodegeneration[@tansley2007][
Molecular Weight	67 kDa
Exons	23
Pathways	Cholesterol
UniProt ID	P45878
NCBI Gene ID	26273
Ensembl ID	ENSG00000160179
OMIM	603076
GeneCards	ABCG1
Human Protein Atlas	ABCG1
Associated Diseases	AD, Als, Alzheimer, AMI, ARM
Known Drugs/Compounds	quercetin
Interactions	4E-BP1, ABCA1, ABCA7, ACTB, Actin, AKT
KG Connections	253 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ABCG1 — AlphaFold P45878 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ABCG1 Gene

gene · 2366 words

→

ABCG1 Protein

protein · 943 words

→

Pathway Diagram

graph TD
    ABCG1["ABCG1"] -.->|"inhibits"| Atherosclerosis["Atherosclerosis"]
    ABCG1["ABCG1"] -.->|"inhibits"| Mtor["Mtor"]
    ABCG1["ABCG1"] -->|"interacts"| ATP["ATP"]
    ABCG1["ABCG1"] -.->|"inhibits"| MTOR["MTOR"]
    ABCG1["ABCG1"] -->|"interacts"| Als["Als"]
    ABCG1["ABCG1"] -->|"activates"| Atherosclerosis_1["Atherosclerosis"]
    ACTB["ACTB"] -->|"interacts"| ABCG1["ABCG1"]
    P2RY12["P2RY12"] -.->|"inhibits"| ABCG1["ABCG1"]
    APOA1["APOA1"] -->|"interacts"| ABCG1["ABCG1"]
    ULK1["ULK1"] -->|"interacts"| ABCG1["ABCG1"]
    style ABCG1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (185)

Target	Relation	Type	Str
R-HSA-8964058	member_of	pathway	1.00
R-HSA-9029569	member_of	pathway	1.00
R-HSA-1369062	member_of	pathway	1.00
cholesterol accumulation	prevents	mechanism	0.90
cholesterol_efflux	regulates	pathway	0.90
Cholesterol Efflux	mediates	process	0.85
Atherosclerosis	inhibits	disease	0.75
Mtor	inhibits	pathway	0.70
lipid droplet accumulation	inhibits	phenotype	0.70
MTOR	inhibits	gene	0.70
APOE	associated_with	gene	0.70
APOE	treats	gene	0.70
Alzheimer disease	therapeutic_target_for	disease	0.70
cholesterol export	regulates	process	0.70
ATP	interacts_with	gene	0.70
cholesterol homeostasis	participates_in	pathway	0.65
ALS	regulates	disease	0.65
Tumor	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Als	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
ALS	inhibits	disease	0.65
ABCA1	regulates	gene	0.60
PARP1	inhibits	gene	0.60
PLIN1	inhibits	gene	0.60
PARP1	activates	gene	0.60
PLIN1	activates	gene	0.60
HMGB1	activates	gene	0.60
TNF	activates	gene	0.60
ALS	activates	disease	0.60
AMPK	activates	entity	0.60
epigenetic regulation	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
APOE	regulates	gene	0.60
ABCG4	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
ULK1	interacts_with	gene	0.60
Pi3K/Akt	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
ACTB	activates	entity	0.60
APOA1	activates	entity	0.60

Incoming (68)

Source	Relation	Type	Str
genes-abcg1	describes	wiki	0.95
apoe4	inhibits	disease	0.90
APOE4	inhibits	gene	0.90
LXRβ	regulates	protein	0.70
TREM2	regulates	gene	0.70
APOA1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
EIF4EBP1	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MTOR	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
LOX	interacts_with	gene	0.60
AKT	inhibits	gene	0.60
SQSTM1	interacts_with	gene	0.60
P62	interacts_with	gene	0.60
ABCA1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
PLIN1	inhibits	gene	0.60
PI3K	regulates	gene	0.60
ABCA1	inhibits	gene	0.60
MAP1LC3	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
MAO	inhibits	gene	0.60
GENES	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
APOE	associated_with	gene	0.60
DHCR24	associated_with	gene	0.60
PARP1	inhibits	gene	0.60
P2RY12	inhibits	gene	0.60
quercetin	targets	drug	0.60
ABCD3	expressed_in	gene	0.60
ABCA2	expressed_in	gene	0.60
APOE	regulates	gene	0.60
ABCA1	regulates	gene	0.60
ATP7A	expressed_in	gene	0.60
CKAP4	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
LAMP3	expressed_in	gene	0.60
ARG1	interacts_with	gene	0.60
ABCG4	regulates	gene	0.60
NR1D2	expressed_in	gene	0.60
ATP	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DNA	associated_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
ABCA1	activates	entity	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Selective LXRβ agonists restore ABCA1/ABCG1 expression and A	0.763	neuroscience	APOE4-driven lipid metabolism dysregulat
APOE4 astrocytes exhibit impaired cholesterol efflux via ABC	0.758	neuroscience	APOE4-driven lipid metabolism dysregulat

Mentioning Analyses (3)

Scientific analyses that reference this entity

Is APOE4's reduced lipid binding pathogenic or a compensatory evolutionary adapt

molecular biology | 2026-04-16 | 9 hypotheses Top: 0.824

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.811

APOE4-driven lipid metabolism dysregulation in astrocytes and its role in AD

neuroscience | 2026-04-04 | 7 hypotheses Top: 0.763

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
The expanding world of neuroscience. [PMID:39423798]	Unknown	Cell	2024
Neuroscience: Past and Future. [PMID:29621483]	Unknown	Neuron	2018
Neurolaw and Neuroethics. [PMID:30720413]	Unknown	Camb Q Healthc Ethics	2018
Applied neuroscience. [PMID:25247360]	Cavanagh Patrick	Current biology : CB	2014
Neuroscience in recession? [PMID:21505517]	Unknown	Nat Rev Neurosci	2011

Debates (3)

Multi-agent debates referencing this entity

APOE4 is the strongest genetic risk factor for late-onset AD. How APOE4 specific

closed · Rounds: 4 · Score: 0.78 · 2026-04-22

The skeptic raised evidence that APOE4 carriers show enhanced cholesterol synthe

closed · Rounds: 4 · Score: 0.71 · 2026-04-16

Despite the debate focusing on SEA-AD transcriptomic data, no actual gene expres

closed · Rounds: 4 · Score: 0.76 · 2026-04-16

Related Research

Hypotheses and analyses mentioning ABCG1 in their description or question text

No additional research found