gene

ATP2A2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATP2A2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

0Hypotheses

0Analyses

10Outgoing

4Incoming

0Experiments

0Debates

Summary

SERCA2 calcium pump - roles in calcium homeostasis, ER stress, neurodegeneration, and Darier disease

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🧬 Gene Info

Gene Symbol	ATP2A2
Full Name	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2
Aliases	SERCA2 calcium pump, SERCA2
Chromosome	12q24.11
Protein Family	P-type ATPase family (ion transport)
Function	This process is crucial for
Primary Expression	Ubiquitous, high in brain, heart, skeletal muscle
Molecular Weight	110 kDa
Amino Acids	12 aa
Pathways	Autophagy, Immune Response
UniProt ID	Q93014
NCBI Gene ID	488
GeneCards	ATP2A2
Human Protein Atlas	ATP2A2
ER calcium homeostasis	Maintains high ER calcium concentrations (100-500 μM vs. ~100 nM cytosolic)
Associated Diseases	neurodegeneration
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ATP2A2 — AlphaFold Q93014 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ATP2A2 Gene

gene · 1490 words

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ATP2A2 Protein (SERCA2)

protein · 629 words

→

Pathway Diagram

graph TD
    ATP2A2["ATP2A2"]
    Infection{"Infection"}
    ATP2A2 -->|"regulates"| Infection
    Als{"Als"}
    ATP2A2 -->|"regulates"| Als
    LC3B(["LC3B"])
    ATP2A2 -->|"regulates"| LC3B
    AUTOPHAGY(["AUTOPHAGY"])
    ATP2A2 -->|"regulates"| AUTOPHAGY
    DNA(["DNA"])
    ATP2A2 -->|"regulates"| DNA
    MAP1LC3B(["MAP1LC3B"])
    ATP2A2 -->|"regulates"| MAP1LC3B
    STING1(["STING1"])
    STING1 -->|"regulates"| ATP2A2
    AND(["AND"])
    AND -->|"regulates"| ATP2A2
    style ATP2A2 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (10)

Target	Relation	Type	Str
Als	regulates	disease	0.65
Infection	regulates	disease	0.65
LC3B	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
DNA	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
MAP1LC3B	regulates	gene	0.60
neurons	expressed_in	cell_type	0.60
STING1	regulates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
STING1	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
AND	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATP2A2 in their description or question text

No additional research found