protein

LC3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LC3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1756Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

LC3B is a protein involved in neurodegeneration research. Key relationships include: activates, interacts with, associated with. Associated with AD, ALI, ALS. Connected to 888 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	LC3B
Pathways	Amyloid Beta Clearance
GeneCards	LC3B
Human Protein Atlas	LC3B
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	curcumin, rapamycin
Interactions	ABCA1, ABCD3, ACHE, ACSL4, ACTB, AGING
SciDEX Hypotheses	Exosomal Autophagosome Transfer System
KG Connections	1755 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LC3B["LC3B"] -->|"regulates"| autophagy["autophagy"]
    LC3B["LC3B"] -->|"associated"| AUTOPHAGY["AUTOPHAGY"]
    LC3B["LC3B"] -->|"associated"| LIPOPHAGY["LIPOPHAGY"]
    LC3B["LC3B"] -->|"prevents"| Alzheimer_s_disease["Alzheimer's disease"]
    LC3B["LC3B"] -->|"biomarker for"| autophagy_1["autophagy"]
    LC3B["LC3B"] -->|"regulates"| amyloid_beta["amyloid beta"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| LC3B["LC3B"]
    BEX2["BEX2"] -->|"regulates"| LC3B["LC3B"]
    NDP52["NDP52"] -->|"interacts"| LC3B["LC3B"]
    BNIP3["BNIP3"] -->|"interacts"| LC3B["LC3B"]
    style LC3B fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1002)

Target	Relation	Type	Str
LC3B	encodes	protein	0.00
AUTOPHAGY	associated_with	gene	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Autophagy	associated_with	pathway	1.00
Autophagy	activates	pathway	1.00
AUTOPHAGY	activates	gene	1.00
P62	activates	gene	1.00
Mtor	activates	pathway	1.00
Infection	activates	disease	0.95
Tumor	activates	disease	0.95
Inflammation	activates	disease	0.95
autophagy pathway	participates_in	pathway	0.90
autophagy	regulates	phenotype	0.90
neural stem cells	activates	cell_type	0.90
Autophagosome Formation	biomarker_for	process	0.90
Autophagy	inhibits	pathway	0.90
Mitophagy	activates	pathway	0.90
Autophagy	interacts_with	pathway	0.90
MTOR	activates	gene	0.90
Apoptosis	activates	pathway	0.90
P62	associated_with	gene	0.90
Amyloid Beta Clearance	involved_in	process	0.88
Mitophagy	associated_with	process	0.87
Breast Cancer	activates	disease	0.85
Als	interacts_with	disease	0.85
Als	regulates	disease	0.85
PINK1-PRKN mitophagy	part_of	pathway	0.85
mitophagy	part_of	pathway	0.85
autophagy	part_of	pathway	0.85
Parkinson's disease	regulates	disease	0.80
PPP2	modulates	protein	0.80
PPP2	interacts_with	protein	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
LIPOPHAGY	associated_with	gene	0.80
apoptosis pathway	participates_in	pathway	0.80
neural stem cells	regulates	cell_type	0.80
P62	inhibits	gene	0.80
PARKIN	activates	gene	0.80
MAP1LC3B	interacts_with	gene	0.80
MAP1LC3B	activates	gene	0.80
UBIQUITIN	interacts_with	gene	0.80
NBR1	activates	gene	0.80
SQSTM1	activates	gene	0.80
Autophagy	expressed_in	pathway	0.80
CGAS-STING	activates	gene	0.80
AUTOPHAGY	expressed_in	gene	0.80
Tumor	expressed_in	disease	0.75
Cancer	associated_with	disease	0.75

Incoming (754)

Source	Relation	Type	Str
LC3B	encodes	gene	0.00
AUTOPHAGY	activates	gene	1.00
LC3	activates	gene	1.00
CANCER	activates	gene	1.00
Thermal Adaptation	upregulates	process	0.90
CALCOCO2	interacts_with	protein	0.90
Amyloid Beta	upregulates	protein	0.90
APOPTOSIS	activates	gene	0.90
CGAS	activates	gene	0.90
AUTOPHAGY	inhibits	gene	0.90
P62	activates	gene	0.90
ATG2A	interacts_with	gene	0.88
Thermal adaptation	upregulates	process	0.85
FURIN	regulates	gene	0.80
Nobiletin	upregulates	compound	0.80
BEX2	regulates	protein	0.80
BNIP3	interacts_with	protein	0.80
NDP52	interacts_with	protein	0.80
ROS	activates	gene	0.80
MTORC1	activates	gene	0.80
MITOPHAGY	activates	gene	0.80
STING	activates	gene	0.80
OPTN	interacts_with	gene	0.80
AUTOPHAGY	interacts_with	gene	0.80
INFLAMMATION	activates	gene	0.80
LC3	interacts_with	gene	0.80
AUTOPHAGY	associated_with	gene	0.80
AMPK	regulates	gene	0.70
NF-ΚB	regulates	gene	0.70
SQSTM1	activates	gene	0.70
ATG7	associated_with	gene	0.70
rapamycin	targets	drug	0.70
ATG7	activates	gene	0.70
NDP52	activates	gene	0.70
ATG	regulates	gene	0.70
AKT	regulates	protein	0.70
PINK1	activates	gene	0.70
FERROPTOSIS	associated_with	gene	0.70
DNM1L	interacts_with	gene	0.70
FUNDC1	interacts_with	gene	0.70
INFLAMMATION	inhibits	gene	0.70
LYSOSOME	activates	gene	0.70
CTSD	regulates	gene	0.70
PTEN	activates	gene	0.70
SQSTM1	associated_with	gene	0.70
GAPDH	activates	gene	0.70
LAMP1	activates	gene	0.70
CANCER	associated_with	gene	0.70
TFEB	activates	gene	0.70
MTDNA	activates	gene	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Exosomal Autophagosome Transfer System	0.000	-	How do non-cell autonomous effects of au

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.390

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

closed · Rounds: 4 · Score: 0.94 · 2026-04-10

Related Research

Hypotheses and analyses mentioning LC3B in their description or question text

No additional research found

LC3B

Understanding Entity Pages

Summary

Wiki Pages (5)

MAP1LC3B — LC3B

MAP1LC3B2 Protein

MAP1LC3B2 Gene

LC3B Protein

MAP1LC3B Protein (LC3B)

Pathway Diagram

Outgoing (1002)

Incoming (754)

Targeting Hypotheses (1)

Mentioning Analyses (1)

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

Experiments (0)

Related Papers (0)

Debates (1)

How do non-cell autonomous effects of autophagy dysfunction contribute to ALS pa

Related Research