gene

MAP1LC3B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAP1LC3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1994Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

Microtubule-Associated Protein 1 Light Chain 3 Beta in autophagy and neurodegenerative diseases

View on Wiki →

🧬 Gene Info

Gene Symbol	MAP1LC3B
Full Name	Microtubule-associated proteins 1A/1B light chain 3B
Aliases	LC3B
Chromosome	16q24.2
Function	MAP1LC3B encodes LC3B, a key protein in the autophagy pathway.
Primary Expression	Ubiquitous, high in brain (neurons and glia), liver, heart, skeletal muscle
Molecular Weight	~14.5 kDa
Amino Acids	125 aa
Pathways	Apoptosis, Autophagy, Immune Response, Innate Immunity, Mapk
UniProt ID	Q9GZQ8
NCBI Gene ID	81631
Ensembl ID	ENSG00000140941
OMIM	609605
GeneCards	MAP1LC3B
Human Protein Atlas	MAP1LC3B
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	rapamycin, cocaine, LPS
Interactions	GBA, FUNDC1, AMBRA1, PINK1, BCL2L13, NLRP3
KG Connections	1993 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAP1LC3B — AlphaFold Q9GZQ8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAP1LC3B["MAP1LC3B"] -->|"encodes"| LC3B["LC3B"]
    MAP1LC3B["MAP1LC3B"] -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| Ischemia["Ischemia"]
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| Ms["Ms"]
    MAP1LC3B["MAP1LC3B"] -->|"interacts"| Dementia["Dementia"]
    MAP1LC3B["MAP1LC3B"] -->|"interacts"| Cardiovascular["Cardiovascular"]
    ACTB["ACTB"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    PPARA["PPARA"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    CAT["CAT"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    SQSTM1["SQSTM1"] -->|"regulates"| MAP1LC3B["MAP1LC3B"]
    style MAP1LC3B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1130)

Target	Relation	Type	Str
Autophagy	associated_with	pathway	1.00
Autophagy	activates	pathway	1.00
Als	activates	disease	1.00
Aβ Clearance	involved_in	process	0.94
Aβ Aggregates	suppresses	process	0.92
amyloid beta	inhibits	protein	0.90
cognitive function	protects_against	phenotype	0.90
ALZHEIMER'S DISEASE	involved_in	disease	0.90
oxidative stress response	participates_in	pathway	0.90
ubiquitin-proteasome	participates_in	pathway	0.90
neural stem cells	activates	cell_type	0.90
neural stem cells	regulates	cell_type	0.90
Autophagy	regulates	pathway	0.90
Neurodegeneration	activates	disease	0.85
Inflammation	activates	disease	0.85
Als	regulates	disease	0.85
Autophagy	biomarker_for	process	0.85
Autophagy	component_of	process	0.85
CD274	binds	protein	0.85
BECN1	participates_in	gene	0.80
SQSTM1	participates_in	gene	0.80
HSPB8	participates_in	gene	0.80
BAG3	participates_in	gene	0.80
HSPD1	biomarker_for	gene	0.80
OPTN	regulates	gene	0.80
PRKN	regulates	gene	0.80
Mitophagy	involved_in	process	0.80
Parkinson's disease	activates	disease	0.80
Parkinson's disease	regulates	disease	0.80
RNA	activates	gene	0.80
apoptosis pathway	participates_in	pathway	0.80
Autophagy	involved_in	process	0.80
Mtor	associated_with	pathway	0.80
AUTOPHAGY	associated_with	gene	0.80
AUTOPHAGY	activates	gene	0.80
MITOCHONDRIA	activates	gene	0.80
Cancer	associated_with	disease	0.75
Cancer	activates	disease	0.75
Carcinoma	associated_with	disease	0.75
Inflammation	inhibits	disease	0.75
Als	inhibits	disease	0.75
Parkinson	regulates	disease	0.75
Neuroinflammation	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Inflammation	regulates	disease	0.75
Infection	regulates	disease	0.75
Aging	implicated_in	disease	0.75
RAS	activates	gene	0.75
MTOR	associated_with	gene	0.70
NCOA4	associated_with	gene	0.70

Incoming (864)

Source	Relation	Type	Str
AUTOPHAGY	associated_with	gene	1.00
Menin	regulates	protein	0.97
amyloid beta	contributes_to	protein	0.90
Dopamine-Conjugated Extracellular Vesicles	upregulates	compound	0.90
CD274/PD-L1	interacts_with	protein	0.90
Tspan1	binds	protein	0.90
Autophagy	upregulates	process	0.90
CD274	interacts_with	protein	0.90
rapamycin	targets	drug	0.90
LC3	associated_with	gene	0.90
ROS	associated_with	gene	0.90
TFEB	upregulates	protein	0.85
autophagy	regulates	pathway	0.80
SQSTM1	participates_in	gene	0.80
AR	activates	gene	0.80
LAMP2	regulates	gene	0.80
CKLF	contributes_to	protein	0.80
CKLF1	contributes_to	gene	0.80
CKLF	upregulates	protein	0.80
DNA	activates	gene	0.80
BECN1	associated_with	gene	0.80
P62	associated_with	gene	0.80
SQSTM1	activates	gene	0.80
P62	activates	gene	0.80
TLR4	inhibits	protein	0.80
LC3B	activates	gene	0.80
ATG	associated_with	gene	0.80
AUTOPHAGY	activates	gene	0.80
AUTOPHAGY	regulates	gene	0.80
LC3B	interacts_with	gene	0.80
NEURODEGENERATION	activates	gene	0.80
ATG5	associated_with	gene	0.75
DNM1L	interacts_with	gene	0.70
LC3	interacts_with	gene	0.70
DRP1	interacts_with	gene	0.70
SQSTM1	associated_with	gene	0.70
BECN1	regulates	gene	0.70
LAMP1	associated_with	gene	0.70
ATG7	activates	gene	0.70
PINK1	activates	gene	0.70
ATG7	associated_with	gene	0.70
MAP1LC3A	associated_with	gene	0.70
amyloid beta	activates	protein	0.70
PPARA	activates	gene	0.70
FURIN deficiency	inhibits	process	0.70
TFEB	activates	protein	0.70
chloroquine	regulates	drug	0.70
cocaine	activates	drug	0.70
GPX4	associated_with	gene	0.70
PTEN	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

MAP1LC3B

Understanding Entity Pages

Summary

Wiki Pages (21)

MAP1LC3B — LC3B

Spinal Cord Dorsal Horn Neurons

autophagy-lysosome-dysfunction

MAP1LC3A Gene

PARK2 - Parkin

PARK2 Protein

txnip

ATG4B — Autophagy Related 4B Cysteine Peptidase

TFEB Signaling in Neurodegeneration

tubb3-protein

LRP2 — Low Density Lipoprotein Receptor-Related Protein 2 (Megalin)

ATG9L1 (Autophagy Related 9 Like 1)

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

TFEB-Mediated Lysosomal Biogenesis

CDKN1B — Cyclin-Dependent Kinase Inhibitor 1B

CBLN1 Gene

TOMM20 — Translocase of Outer Mitochondrial Membrane 20

SOX9 Gene

TOMM20 Protein

ATP2A2 Gene

TUBB3 Protein