Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Blood-Brain Barrier Breakdown: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neuroinflammation | causes | mechanism | 0.95 |
| neurodegeneration | causes | disease | 0.95 |
| Vascular Brain Injury | contributes_to | process | 0.85 |
| Alzheimer disease | associated_with | disease | 0.70 |
| major depressive disorder | causes | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 35139885 | causes acceleration of | paper | 0.90 |
| TDP43 | contributes_to | protein | 0.90 |
| 26883501 | contribute to | paper | 0.90 |
| 25611508 | worsens with | paper | 0.90 |
| 25611508 | is | paper | 0.90 |
| Hypoxia | causes | process | 0.90 |
| TDP43 Depletion | causes | mechanism | 0.90 |
| TNF/NF-κB Signaling | contributes_to | pathway | 0.75 |
| mTOR | activates | protein | 0.70 |
| TNF | activates | protein | 0.70 |
| 25611508 | correlates with | paper | 0.60 |
| 25611508 | contributes to | paper | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Soluble PDGFRβ as a Peripheral Indicator of Pericyte-Mediate | 0.705 | - | What blood-brain barrier permeability ch |
| Vascular Cell Type Crosstalk Driving Blood-Brain Barrier Bre | 0.662 | neurodegeneration | Methodology challenge: dataset 'Allen Br |
| TREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blo | 0.499 | neuroscience | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 1 hypotheses Top: 0.380
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.76 · 2026-04-12
closed · Rounds: 4 · Score: 0.78 · 2026-04-12
closed · Rounds: 4 · Score: 0.50 · 2026-04-11
Hypotheses and analyses mentioning Blood-Brain Barrier Breakdown in their description or question text
No additional research found