concept

MAJOR DEPRESSIVE DISORDER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAJOR DEPRESSIVE DISORDER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

1Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MAJOR DEPRESSIVE DISORDER

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MAJOR_DEPRESSIVE_DISORDER["MAJOR DEPRESSIVE DISORDER"]
    MAJOR_DEPRESSIVE_DISORDER -->|"causes"| disability["disability"]
    esketamine["esketamine"] -->|"treats"| MAJOR_DEPRESSIVE_DISORDER
    ALKBH5["ALKBH5"] -.biomarker for.-> MAJOR_DEPRESSIVE_DISORDER
    tryptophan["tryptophan"] -.biomarker for.-> MAJOR_DEPRESSIVE_DISORDER
    kynurenic_acid["kynurenic acid"] -.biomarker for.-> MAJOR_DEPRESSIVE_DISORDER
    amphiregulin["amphiregulin"] -.protects against.-> MAJOR_DEPRESSIVE_DISORDER
    psychotherapy["psychotherapy"] -->|"treats"| MAJOR_DEPRESSIVE_DISORDER
    DLPFC_OFC_connectivity["DLPFC-OFC connectivity"] -.biomarker for.-> MAJOR_DEPRESSIVE_DISORDER
    indoxyl_sulfate["indoxyl sulfate"] -.biomarker for.-> MAJOR_DEPRESSIVE_DISORDER

Outgoing (1)

Target	Relation	Type	Str
disability	causes	phenotype	0.85

Incoming (62)

Source	Relation	Type	Str
esketamine	treats	drug	0.95
Selective Serotonin Reuptake Inhibitors	treats	drug	0.95
Stress-Induced Immune Dysregulation	associated_with	process	0.95
BDNF	involved_in	gene	0.90
Neuroplasticity	contributes_to	process	0.90
Impaired Synaptic Plasticity	contributes_to	process	0.90
FLOT1	associated_with	protein	0.90
NECL1	involved_in	gene	0.90
tryptophan	biomarker_for	metabolite	0.85
kynurenic acid	biomarker_for	metabolite	0.85
Engeletin	treats	compound	0.85
Serotonin	contributes_to	compound	0.85
HMGB1	biomarker_for	protein	0.85
NECL1 deficiency	contributes_to	phenotype	0.85
ALKBH5	biomarker_for	gene	0.85
amphiregulin	protects_against	protein	0.82
psychotherapy	treats	process	0.80
DLPFC-OFC connectivity	biomarker_for	process	0.80
indoxyl sulfate	biomarker_for	metabolite	0.80
energy metabolism	associated_with	pathway	0.80
neuroprotection	protects_against	process	0.80
gut microbiota	implicated_in	cell_type	0.80
Grape-Derived Polyphenols	treats	compound	0.80
S100B	biomarker_for	protein	0.80
BDNF	biomarker_for	protein	0.75
apoptosis	associated_with	process	0.75
BCL2	associated_with	gene	0.70
NLRP3 inflammasome	associated_with	protein	0.70
BGP-15	treats	drug	0.70
TNF	associated_with	protein	0.70
blood-brain barrier breakdown	causes	process	0.70
EZH2	associated_with	gene	0.70
BDNF	associated_with	protein	0.70
neurogenesis	associated_with	process	0.70
NLRP1	associated_with	protein	0.70
autophagy	associated_with	process	0.70
NLRP1	associated_with	protein	0.70
autophagy	associated_with	process	0.70
BDNF	protects_against	protein	0.70
neuroinflammation	causes	process	0.70
gut microbiota	associated_with	process	0.70
gut microbiota modulation	treats	process	0.70
microbial dysbiosis	associated_with	process	0.70
gut microbiota dysbiosis	causes	process	0.70
immunity	associated_with	process	0.70
gut microbiota dysbiosis	associated_with	process	0.70
epigenetics	associated_with	process	0.70
immune system	associated_with	process	0.70
stress disorders	associated_with	disease	0.70
NLRP3	associated_with	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAJOR DEPRESSIVE DISORDER

Understanding Entity Pages

Wiki Pages (20)

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