gene

CAMK2D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAMK2D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

14Outgoing

1Incoming

0Experiments

Summary

CAMK2D encodes CaM kinase II delta, a key synaptic plasticity kinase with critical roles in learning, memory, and neuronal survival in Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	CAMK2D
Full Name	Calcium/Calmodulin-Dependent Protein Kinase II Delta
Aliases	Calcium/Calmodulin-Dependent Kinase 2 Delta
Chromosome	8q21.11
Primary Expression	the mammalian brain (α, β, γ, and δ), with CaMKIIδ being particularly abundant in subcortical structures and non-neuronal tissues
Subcellular Localization	The holoenzyme architecture allows for cooperative activation and inter-subunit autophosphorylation, creating a molecula
Pathways	Autophagy-Lysosome Pathway
UniProt ID	Q9UQM7
NCBI Gene ID	817
Ensembl ID	ENSG00000145349
OMIM	607878
GeneCards	CAMK2D
Human Protein Atlas	CAMK2D
Encoded Protein	CaM kinase II delta (CaMKIIδ)
Associated Diseases	Parkinson's disease
Known Drugs/Compounds	Schaftoside
Interactions	PEAK2, PLCγ1
KG Connections	14 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CAMK2D — AlphaFold Q9UQM7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CAMK2D["<b>CAMK2D</b>"]
    PEAK1["PEAK1"]
    CAMK2D -->|"binds"| PEAK1
    RBM20["RBM20"]
    CAMK2D -->|"regulates"| RBM20
    TTN["TTN"]
    CAMK2D -->|"regulates"| TTN
    Atf6["Atf6"]
    CAMK2D -->|"upregulates"| Atf6
    Sod1["Sod1"]
    CAMK2D -->|"upregulates"| Sod1
    PEAK2["PEAK2"]
    CAMK2D -->|"interacts with"| PEAK2
    PLC_1["PLCgamma1"]
    CAMK2D -->|"activates"| PLC_1
    Parkinson_s_disease{"Parkinson's disease"}
    CAMK2D -->|"associated with"| Parkinson_s_disease
    neurodegeneration["neurodegeneration"]
    CAMK2D -->|"implicated in"| neurodegeneration
    style CAMK2D fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
PEAK1	binds	gene	0.90
RBM20	regulates	gene	0.90
TTN	regulates	gene	0.90
Autophagy-Lysosome Pathway	regulates	pathway	0.85
Atf6	upregulates	gene	0.80
PEAK2	interacts_with	gene	0.80
PLCγ1	activates	protein	0.80
Sod1	upregulates	gene	0.80
Parkinson's disease	associated_with	disease	0.80
necroinflammatory signaling	modulates	pathway	0.75
EP300	associated_with	gene	0.60
NCOR1	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
XPO1	associated_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
Schaftoside	targets	compound	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found