gene

Sod1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Sod1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2775Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

Sod1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, contributes to, activates. Associated with ALS, Aging, Alzheimer. Connected to 159 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	SOD1
Full Name	Superoxide Dismutase 1
Chromosome	21q22.11
Protein Type	Enzyme
Function	is a copper/zinc-dependent enzyme that catalyzes the dismutation of superoxide radical (O₂⁻) into molecular oxygen (O₂) and hydrogen peroxide (H₂O₂).
Primary Expression	Motor cortex, Spinal cord, Widespread throughout CNS
Molecular Weight	16 kDa
Amino Acids	154 aa
Pathways	Amyloid, Apoptosis, Autophagy, Epigenetic, Er Stress
Ensembl ID	ENSG00000142168
GeneCards	SOD1
Human Protein Atlas	SOD1
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Huntington, Neurodegeneration, Parkinson
Interactions	CTSB, PPP3CB, LAMP2A, BCL2, HSPA8, TPP1
KG Connections	680 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: Sod1 — PDB 2C9V Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CAMK2D["CAMK2D"] -->|"regulates"| Sod1["Sod1"]
    PRKCD["PRKCD"] -->|"activates"| Sod1["Sod1"]
    TREHALOSE["TREHALOSE"] -->|"activates"| Sod1["Sod1"]
    MTOR["MTOR"] -->|"associated"| Sod1["Sod1"]
    style Sod1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1425)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.60
Amyotrophic Lateral Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Als	associated_with	disease	0.60
Huntington	associated_with	disease	0.60
Frontotemporal Dementia	therapeutic_target	disease	0.60
Dementia	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Als	therapeutic_target	disease	0.60
Aging	therapeutic_target	disease	0.60
Neurodegeneration	regulates	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Als	biomarker_for	disease	0.60
Amyotrophic Lateral Sclerosis	regulates	disease	0.60
Necroptosis	regulates	disease	0.60
Als	regulates	disease	0.60
Als	expressed_in	disease	0.60
Amyotrophic Lateral Sclerosis	inhibits	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Multiple Sclerosis	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Huntington	therapeutic_target	disease	0.60
Neuroinflammation	therapeutic_target	disease	0.60
Als	inhibits	disease	0.60
Cancer	activates	disease	0.60
Aging	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Dementia	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Als	activates	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Alzheimer	inhibits	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Stroke	inhibits	disease	0.60
Parkinson	inhibits	disease	0.60
Ischemia	inhibits	disease	0.60
Diabetes	activates	disease	0.60
Amyotrophic Lateral Sclerosis	contributes_to	disease	0.60
Neuroinflammation	interacts_with	disease	0.60
Alzheimer	interacts_with	disease	0.60
Neurodegeneration	protects_against	disease	0.60
Neuroinflammation	protects_against	disease	0.60
Als	protects_against	disease	0.60
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Amyotrophic Lateral Sclerosis	causes	disease	0.60
Neurodegeneration	causes	disease	0.60
Als	causes	disease	0.60

Incoming (1350)

Source	Relation	Type	Str
CAMK2D	upregulates	gene	0.80
PRKCD	activates	gene	0.80
TREHALOSE	activates	gene	0.60
MTOR	associated_with	gene	0.60
P62	associated_with	gene	0.60
DNA	associated_with	gene	0.60
TPP1	associated_with	gene	0.60
PPP3	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TREH	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
STUB1	associated_with	gene	0.60
ATG	associated_with	gene	0.60
STIP1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
ALS	associated_with	gene	0.60
CTSB	associated_with	gene	0.60
PPP3CB	associated_with	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ATG10	activates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
GLA	associated_with	gene	0.60
LAMP1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
MAP1LC3B	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
ATG12	activates	gene	0.60
BECN1	associated_with	gene	0.60
HSPB8	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
BAG3	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
CALCINEURIN	activates	gene	0.60
BCL2	associated_with	gene	0.60
GENES	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
JUN	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
SOD1	causes	gene	0.60
ALS	causes	gene	0.60
TARDBP	inhibits	gene	0.60
SOD1 MUTATIONS	associated_with	gene	0.60
DEMENTIA	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-02 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Sod1

Understanding Entity Pages

Summary

Wiki Pages (20)

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

nimodipine-als

Therapeutics

NPM1 Gene

neuroinflammation

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

HNRNPA2B1 Protein

ALS Failed Approaches Analysis

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

oxidative-stress-comparison

Blood-Brain Barrier Dysfunction in Neurodegeneration

Neurotrophin Signaling Pathways in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Pathway Diagram

Outgoing (1425)

Incoming (1350)

Targeting Hypotheses (0)

Mentioning Analyses (2)

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Related Papers (0)