gene

NCOR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCOR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

58Connections

0Hypotheses

0Analyses

49Outgoing

9Incoming

Summary

Page for NCOR1 Gene - Nuclear Receptor Corepressor 1

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🧬 Gene Info

Gene Symbol	NCOR1
Full Name	Nuclear Receptor Corepressor 1
Aliases	Page for NCOR1 Gene
Chromosome	17p12-p11.2
Function	NCOR1 is a component of several corepressor complexes that regulate gene expression through chromatin remodeling
Primary Expression	Brain (high), particularly cortex and hippocampus
Amino Acids	440 aa
Exons	24
Pathways	Oxidative Stress, Proteasome
UniProt ID	O75376
NCBI Gene ID	9612
Ensembl ID	ENSG00000140989
OMIM	607079
GeneCards	NCOR1
Human Protein Atlas	NCOR1
Associated Diseases	Cancer
Interactions	SIRT1, RNF20, UBIQUITIN, ITGA3, SGK1, BDNF
KG Connections	58 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NCOR1 — AlphaFold O75376 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NCOR1["<b>NCOR1</b>"]
    Carcinoma{"Carcinoma"}
    NCOR1 -->|"activates"| Carcinoma
    Obesity{"Obesity"}
    NCOR1 -->|"activates"| Obesity
    Als{"Als"}
    NCOR1 -->|"activates"| Als
    Atherosclerosis{"Atherosclerosis"}
    NCOR1 -->|"activates"| Atherosclerosis
    Neuroinflammation{"Neuroinflammation"}
    NCOR1 -->|"activates"| Neuroinflammation
    SIRT1(["SIRT1"])
    SIRT1 -->|"activates"| NCOR1
    PPAR(["PPAR"])
    PPAR -->|"activates"| NCOR1
    NR4A2(["NR4A2"])
    NR4A2 -->|"activates"| NCOR1
    HMGB1(["HMGB1"])
    HMGB1 -.->|"inhibits"| NCOR1
    style NCOR1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (49)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Obesity	activates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	associated_with	disease	0.65
SIRT1	activates	gene	0.60
RNF20	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ITGA3	activates	gene	0.60
SGK1	activates	gene	0.60
BDNF	activates	gene	0.60
Jnk	regulates	protein	0.60
NR4A1	activates	gene	0.60
Jnk	inhibits	protein	0.60
UBIQUITIN	regulates	gene	0.60
BACH1	associated_with	gene	0.60
ATRX	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
RB1	associated_with	gene	0.60
TFE3	associated_with	gene	0.60
Rb	associated_with	protein	0.60
TCF7L2	transports	gene	0.60
MITF	transports	gene	0.60
PIK3CA	associated_with	gene	0.60
XPO1	associated_with	gene	0.60
Proteasome	activates	pathway	0.60
P21	activates	gene	0.60
AND	activates	gene	0.60
Epithelial	activates	cell_type	0.60
T Cell	activates	cell_type	0.60
RNA	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
Actin	regulates	protein	0.60
CCL2	interacts_with	gene	0.60
App	activates	protein	0.60
COX2	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
INOS	inhibits	gene	0.60
Oxidative Stress	regulates	pathway	0.60
DNA	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
P53	associated_with	protein	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
MAPK	therapeutic_target	gene	0.60
Cortex	expressed_in	brain_region	0.55

Incoming (9)

Source	Relation	Type	Str
SIRT1	activates	gene	0.60
PPAR	activates	gene	0.60
NR4A2	activates	gene	0.60
HMGB1	inhibits	gene	0.60
LRP1B	associated_with	gene	0.60
TP53	associated_with	gene	0.60
ARNT2	transports	gene	0.60
CAMK2D	associated_with	gene	0.60
EP300	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NCOR1

Understanding Entity Pages

Summary

Wiki Pages (8)

NCOR1 Gene - Nuclear Receptor Corepressor 1

sporadic-familial-pd-comparison

PPAR Signaling Pathway in Neurodegeneration

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

Striatal Medium Spiny Neurons in Huntington's Disease

REV-ERBα Protein