gene

PIK3CA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

780Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

PIK3CA is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, interacts with. Associated with Aging, Als, Amyotrophic Lateral Sclerosis. Connected to 338 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PIK3CA
Chromosome	3q26.32
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	120 kDa
Amino Acids	068 aa
Exons	21
Pathways	PI3K, mTOR
GeneCards	PIK3CA
Human Protein Atlas	PIK3CA
PIP2	PIP3
PI(4)P	PI(3,4)P2
PI	PI(3)P
Approach	Agent
PI3K inhibitors	Wortmannin, LY294002
Akt inhibitors	Akti-1/2
Associated Diseases	ALS, Aging, BREAST CANCER
Known Drugs/Compounds	Chrysotoxine, Apitolisib, Paxalisib, Alpelisib, rapamycin
Interactions	PTEN, AKT, PI3K, MMP9, PPARA, IGF1R
KG Connections	779 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PIK3CA["PIK3CA"]
    PIK3CA -->|"causes"| ESCC["ESCC"]
    PIK3CA -->|"activates"| MTOR["MTOR"]
    PIK3CA -->|"activates"| mTOR["mTOR"]
    PIK3CA -->|"target for"| Heart_Failure["Heart Failure"]
    PIK3CA -->|"target for"| Ms["Ms"]
    PIK3CA -->|"regulates"| Cancer["Cancer"]
    PIK3CA -->|"inhibits"| Tumor["Tumor"]
    PIK3CA -->|"target for"| Carcinoma["Carcinoma"]
    PI3K["PI3K"] -->|"regulates"| PIK3CA
    MDM2["MDM2"] -->|"regulates"| PIK3CA

Outgoing (481)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Tumor	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
Tumor	therapeutic_target	disease	1.00
AKT	therapeutic_target	gene	1.00
Diffuse Intrinsic Pontine Glioma	associated_with	disease	0.95
AKT1	activates	protein	0.95
AKT	upstream_of	protein	0.95
Pi3K/Akt/Mtor Pathway	involved_in	pathway	0.95
Pi3K-Akt-Mtor Pathway	activates	pathway	0.95
PI3K-Akt-mTOR Pathway	activates	pathway	0.90
PI3K	encodes	protein	0.90
Pi3K/Akt/Mtor Pathway	associated_with	pathway	0.90
ESCC	causes	disease	0.90
PI3K-AKT-mTOR signaling	participates_in	pathway	0.90
Pi3K/Akt	inhibits	pathway	0.90
Bladder Cancer Metabolism	regulates	phenotype	0.85
niche formation	activates	process	0.85
Tumor	inhibits	disease	0.85
Als	associated_with	disease	0.85
Aging	therapeutic_target	disease	0.85
Breast Cancer	therapeutic_target	disease	0.85
Cancer	inhibits	disease	0.85
PI3K/AKT/mTOR	activates	pathway	0.85
HIF1A	activates	gene	0.82
Chrysotoxine	interacts_with	compound	0.80
cell proliferation	promotes	process	0.80
Breast cancer	causes	disease	0.80
Vascular Niche Formation	involved_in	process	0.80
MAPK signaling	participates_in	pathway	0.80
MTOR	activates	protein	0.80
AKT	inhibits	gene	0.80
Pi3K/Akt	therapeutic_target	pathway	0.80
Trastuzumab Deruxtecan	associated_with	drug	0.75
Cancer	regulates	disease	0.75
Carcinoma	therapeutic_target	disease	0.75
Cancer	interacts_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Als	inhibits	disease	0.75
Colorectal Cancer	inhibits	disease	0.75
Breast Cancer	inhibits	disease	0.75
AKT	interacts_with	gene	0.70
MTOR	therapeutic_target	gene	0.70
PIK3R1	therapeutic_target	gene	0.70
AKT	contributes_to	gene	0.70
MTOR	contributes_to	gene	0.70
mTOR	activates	protein	0.70
Mtor	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70

Incoming (299)

Source	Relation	Type	Str
PI3K	inhibits	gene	1.00
CANCER	therapeutic_target	gene	1.00
Alpelisib	inhibits	drug	0.95
Paxalisib	inhibits	drug	0.90
PI3K	therapeutic_target	gene	0.90
CANCER	associated_with	gene	0.90
KRAS	associated_with	gene	0.90
Apitolisib	inhibits	drug	0.85
RLN	phosphorylates	protein	0.85
P2Ry12	activates	protein	0.85
Chrysotoxine	targets	compound	0.80
PTEN	therapeutic_target	gene	0.80
CANCER	inhibits	gene	0.80
ARID1A	associated_with	gene	0.70
PTEN	associated_with	gene	0.70
CLCN8	associated_with	gene	0.70
JAK2	therapeutic_target	gene	0.70
TP53	therapeutic_target	gene	0.70
PI3K	activates	gene	0.70
PI3K	contributes_to	gene	0.70
EGFR	therapeutic_target	gene	0.70
IGF1R	interacts_with	gene	0.70
TP53	associated_with	gene	0.70
APC	associated_with	gene	0.70
PTEN	inhibits	gene	0.70
MAPK1	targets	gene	0.70
MAPK1	associated_with	gene	0.70
PI3K	treats	gene	0.70
GENES	associated_with	gene	0.70
APOPTOSIS	therapeutic_target	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
MTOR PATHWAY	regulates	pathway	0.65
CDK4	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
PI3K	regulates	gene	0.60
ESR1	associated_with	gene	0.60
CHEK1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
MDM2	regulates	gene	0.60
STAT3	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
MTOR	inhibits	gene	0.60
TNF	therapeutic_target	gene	0.60
BRCA1	therapeutic_target	gene	0.60
PALB2	therapeutic_target	gene	0.60
EGFR	activates	gene	0.60
AKT	inhibits	gene	0.60
HRAS	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
MAPK1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PIK3CA

Understanding Entity Pages

Summary

Wiki Pages (21)

PIK3CA Gene

rankings

NTF5 — Neurotrophin 5

GAB2 — GRB2 Associated Binding Protein 2

pi3k-akt-signaling

MAP2K2 Gene

PCDH15 — Protocadherin 15

GSK3B Protein (Glycogen Synthase Kinase 3 Beta)

Thioflavin-T Fluorescence Assay for Protein Aggregation

PI3K/Akt Signaling in Neurodegeneration

GFRA4 - GDNF Family Receptor Alpha 4

PIK3R3 Gene

PI3K/Akt Signaling in Parkinson's Disease

AKT1 Protein

AKT (Protein Kinase B) Neurons

PI3K — Phosphoinositide 3-Kinase

PIK3R2 Gene

SGK3 - Serum/Glucocorticoid Regulated Kinase 3

PPP2CA — Protein Phosphatase 2 Catalytic Subunit Alpha