gene

CDNF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

32Connections

1Hypotheses

0Analyses

25Outgoing

7Incoming

0Experiments

0Debates

Summary

CDNF Gene

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🧬 Gene Info

Gene Symbol	CDNF
Full Name	Cerebral Dopamine Neurotrophic Factor
Chromosome	10p13
Protein Family	MANF/CDNF family
Function	CDNF performs several critical functions in the nervous system:
Primary Expression	the central nervous system, with particularly high expression in dopaminergic regions including the substantia nigra and striatum
Amino Acids	60 aa
UniProt ID	[Q96GS4](https://www.uniprot.org/uniprot/Q96GS4)
GeneCards	CDNF
Human Protein Atlas	CDNF
N-terminal domain (1-60 aa)	Contains an ER retention signal sequence (RSNL) that directs protein to the endoplasmic reticulum. This region is involved in protein-protein interactions and ER homeostasis.
C-terminal domain (61-182 aa)	The secreted portion contains the neurotrophic activity and mediates receptor interactions on target neurons.
Associated Diseases	ALS, Alzheimer, Parkinson
Known Drugs/Compounds	levodopa
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, PARKINSON, PARKINSON'S DISEASE
KG Connections	32 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDNF Gene

gene · 1622 words

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Neurotrophic Factor Gene Therapy Programs — GDNF, CDNF, BDNF, Neurturin

therapeutic · 1535 words

→

Pathway Diagram

graph TD
    CDNF["CDNF"]
    Alzheimer{"Alzheimer"}
    CDNF -->|"therapeutic_target"| Alzheimer
    Als{"Als"}
    CDNF -->|"expressed_in"| Als
    Parkinson{"Parkinson"}
    CDNF -->|"therapeutic_target"| Parkinson
    ALS{"ALS"}
    CDNF -->|"expressed_in"| ALS
    ALZHEIMER(["ALZHEIMER"])
    ALZHEIMER -->|"therapeutic_target"| CDNF
    GDNF(["GDNF"])
    GDNF -->|"expressed_in"| CDNF
    AADC(["AADC"])
    AADC -->|"expressed_in"| CDNF
    PARKINSON(["PARKINSON"])
    PARKINSON -->|"therapeutic_target"| CDNF
    style CDNF fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (25)

Target	Relation	Type	Str
Alzheimer	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
Parkinson	inhibits	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Neuron	therapeutic_target	cell_type	0.60
neurons	expressed_in	cell_type	0.60
GDNF	expressed_in	gene	0.60
AADC	expressed_in	gene	0.60
GDNF	associated_with	gene	0.60
GDNF	protects_against	gene	0.60
Gdnf	expressed_in	protein	0.60
Rb	expressed_in	protein	0.60
ALS	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Alzheimer	associated_with	disease	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
App	therapeutic_target	protein	0.60
PARKINSON	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
Neuron	expressed_in	cell_type	0.55
DOPAMINE	expressed_in	concept	0.50
GDNF	co_expressed_with	gene	0.50

Incoming (7)

Source	Relation	Type	Str
SYP	co_expressed_with	protein	0.85
GDNF	expressed_in	gene	0.60
AADC	expressed_in	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
levodopa	targets	drug	0.60
CEREBRAL DOPAMINE NEUROTROPHIC FACTOR	expressed_in	protein	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Hypothesis 1: MANF/CDNF Signaling as Primary Neuroprotective	0.798	neurodegeneration	Which specific factors in conditioned me

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and reg [PMID:39019902]	Nam J, Richie CT, Harvey BK	Sci Rep	2024
Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Ex [PMID:31105589]	Pöyhönen S, Er S, Domanskyi A, Airavaara	Frontiers in physiology	2019
Unconventional neurotrophic factors CDNF and MANF: Structure, physiological func [PMID:27425895]	Unknown	Neurobiology of disease	2018
Neurorestoration. [PMID:22166416]	Unknown	Parkinsonism & related dis	2012
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in [PMID:17611540]	Lindholm P, Voutilainen MH, Laurén J	Nature	2007

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CDNF in their description or question text

No additional research found