Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDNF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CDNF |
| Full Name | Cerebral Dopamine Neurotrophic Factor |
| Chromosome | 10p13 |
| Protein Family | MANF/CDNF family |
| Function | CDNF performs several critical functions in the nervous system: |
| Primary Expression | the central nervous system, with particularly high expression in dopaminergic regions including the substantia nigra and striatum |
| Amino Acids | 60 aa |
| UniProt ID | Q96GS4 |
| NCBI Gene ID | 124403 |
| Ensembl ID | ENSG00000154917 |
| OMIM | 611088 |
| GeneCards | CDNF |
| Human Protein Atlas | CDNF |
| Associated Diseases | ALS, Alzheimer, Parkinson |
| Known Drugs/Compounds | levodopa |
| Interactions | ALZHEIMER, PARKINSON, ALZHEIMER'S DISEASE, PARKINSON'S DISEASE |
| KG Connections | 33 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CDNF["<b>CDNF</b>"]
Alzheimer{"Alzheimer"}
CDNF -->|"therapeutic_target"| Alzheimer
Als{"Als"}
CDNF -->|"expressed_in"| Als
Parkinson{"Parkinson"}
CDNF -->|"therapeutic_target"| Parkinson
ALS{"ALS"}
CDNF -->|"expressed_in"| ALS
ALZHEIMER(["ALZHEIMER"])
ALZHEIMER -->|"therapeutic_target"| CDNF
GDNF(["GDNF"])
GDNF -->|"expressed_in"| CDNF
AADC(["AADC"])
AADC -->|"expressed_in"| CDNF
PARKINSON(["PARKINSON"])
PARKINSON -->|"therapeutic_target"| CDNF
style CDNF fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| GDNF | expressed_in | gene | 0.60 |
| AADC | expressed_in | gene | 0.60 |
| Gdnf | expressed_in | protein | 0.60 |
| Rb | expressed_in | protein | 0.60 |
| GDNF | associated_with | gene | 0.60 |
| GDNF | protects_against | gene | 0.60 |
| Neuron | therapeutic_target | cell_type | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| PARKINSON'S DISEASE | inhibits | gene | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| ALS | associated_with | disease | 0.60 |
| Parkinson | associated_with | disease | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| GDNF | co_expressed_with | gene | 0.50 |
| DOPAMINE | expressed_in | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||