Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AADC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AADC |
| Summary | Page for Principal Pars Compacta |
| Key Genes/Proteins | TH |
| Related Diseases | Sleep Disorder, Spinal Muscular Atrophy, Alzheimer |
| Related Pathways | oxidative stress response |
Knowledge base pages for this entity
graph TD
AADC["AADC"]
style AADC fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
AADC -->|"catalyzes"| Dopamine["Dopamine"]
AADC -->|"catalyzes"| Tryptamine["Tryptamine"]
AADC -->|"catalyzes"| Dopamine_Synthesis["Dopamine Synthesis"]
AADC -->|"catalyzes"| Serotonin_Synthesis["Serotonin Synthesis"]
AADC -->|"catalyzes"| Serotonin["Serotonin"]
AADC -->|"substrate_of"| L_DOPA["L-DOPA"]
AADC -->|"expressed in"| Non_dopaminergic_Neurons["/Non-dopaminergic Neurons/"]
AADC -->|"implicated in"| neurodegeneration["neurodegeneration"]
AADC -->|"involved_in"| dopamine{"dopamine"}
h_7bb47d7a["h-7bb47d7a"] -->|"targets"| AADC
TH([TH]) -->|"co_expressed_with"| AADC
Therapeutics["Therapeutics"] -->|"references"| AADC
Cell_Types["Cell Types"] -->|"references"| AADC
Gene_Therapy_for_Neurodegenera["Gene Therapy for Neurodegenerative Diseases"] -->|"references"| AADC
NURR1_Agonist_Therapy_for_Park["NURR1 Agonist Therapy for Parkinson's Disease"] -->|"references"| AADC
Drug_Target_Landscape["Drug Target Landscape"] -->|"references"| AADC
Tissue_Engineered_Nigrostriata["Tissue Engineered Nigrostriatal Pathway for Parkinson's Disease"] -->|"references"| AADC
COMT_Inhibitors["COMT Inhibitors"] -->|"references"| AADC
AAV_Vectors_in_Neurodegenerati["AAV Vectors in Neurodegenerative Disease Gene Therapy"] -->|"references"| AADC| Target | Relation | Type | Str |
|---|---|---|---|
| oxidative stress response | participates_in | pathway | 0.90 |
| TH | associated_with | gene | 0.80 |
| serotonin | associated_with | neurotransmitter | 0.80 |
| neurons | associated_with | cell_type | 0.80 |
| TH | releases | gene | 0.70 |
| neurons | treats | cell_type | 0.70 |
| neurons | releases | cell_type | 0.70 |
| Sleep Disorder | expressed_in | disease | 0.65 |
| Spinal Muscular Atrophy | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Huntington | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Parkinson | biomarker_for | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Schizophrenia | inhibits | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Huntington | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| Frontotemporal Dementia | associated_with | disease | 0.65 |
| ALS | biomarker_for | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Anxiety | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Frontotemporal Dementia | therapeutic_target | disease | 0.65 |
| Anxiety | therapeutic_target | disease | 0.65 |
| neurodegeneration | implicated_in | disease | 0.60 |
| serotonin | involved_in | drug | 0.60 |
| tryptamine | involved_in | drug | 0.60 |
| AADC deficiency | causes | disease | 0.60 |
| substantia nigra | expressed_in | brain_region | 0.60 |
| ventral tegmental area | expressed_in | brain_region | 0.60 |
| dopamine synthesis | involved_in | pathway | 0.60 |
| oculogyric crises | associated_with | disease | 0.60 |
| schizophrenia | implicated_in | disease | 0.60 |
| CDNF | expressed_in | gene | 0.60 |
| TAAR1 | regulates | gene | 0.60 |
| AHR | regulates | gene | 0.60 |
| LRRK2 | biomarker_for | gene | 0.60 |
| SUMF1 | biomarker_for | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-7bb47d7a | targets_gene | hypothesis | 0.90 |
| h-7bb47d7a | targets | hypothesis | 0.80 |
| levodopa | targets | drug | 0.80 |
| levodopa | associated_with | compound | 0.70 |
| levodopa | releases | compound | 0.70 |
| TH | co_expressed_with | gene | 0.60 |
| GDNF | expressed_in | gene | 0.60 |
| DDC | biomarker_for | gene | 0.60 |
| SUMF1 | biomarker_for | gene | 0.60 |
| GBA | biomarker_for | gene | 0.60 |
| TAAR1 | inhibits | gene | 0.60 |
| OVERVIEW | therapeutic_target | gene | 0.60 |
| BDNF | therapeutic_target | gene | 0.60 |
| GDNF | therapeutic_target | gene | 0.60 |
| CDNF | expressed_in | gene | 0.60 |
| TAAR1 | regulates | gene | 0.60 |
| AHR | regulates | gene | 0.60 |
| LRRK2 | biomarker_for | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| OVERVIEW | associated_with | gene | 0.60 |
| GDNF | associated_with | gene | 0.60 |
| levodopa | transported_by | compound | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| HUNTINGTON | therapeutic_target | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| DAT | biomarker_for | gene | 0.60 |
| ANXIETY | therapeutic_target | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| ALZHEIMER | inhibits | gene | 0.60 |
| PARKINSON | inhibits | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | inhibits | gene | 0.60 |
| PARKINSON'S DISEASE | inhibits | gene | 0.60 |
| PARKINSON | activates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| PARKINSON'S DISEASE | activates | gene | 0.60 |
| CYP1A2 | regulates | gene | 0.60 |
| MAO-B | regulates | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| CYP1A1 | regulates | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| MAO | regulates | gene | 0.60 |
| DEMENTIA | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| HUNTINGTON'S DISEASE | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| GBA MUTATIONS | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||