gene

SYP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

452Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

SYP is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with Aging, Als, Epilepsy. Connected to 68 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight38 kDa
Amino Acids313 aa
Exons4
PathwaysOxidative Stress
UniProt ID[P08247](https://www.uniprot.org/uniprot/P08247)
Ensembl IDENSG00000157193
OMIM313475
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesAlzheimer, Motor function, Motor function recovery, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsSYNCRIP, SNAP25, MTOR, P38, GFAP, TNF
KG Connections444 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SYP Gene

gene · 785 words

Synaptic Vesicle Trafficking in Parkinson's Disease

mechanism · 4417 words

Allen Human Brain Atlas

dataset · 3555 words

PTBP2 - Polypyrimidine Tract Binding Protein 2

gene · 3381 words

Synaptic Dysfunction Pathway

mechanism · 3282 words

Oxytocin Receptor Neurons

cell · 3138 words

Pathway Diagram

graph TD
    SYP["<b>SYP</b>"]
    Inflammation{"Inflammation"}
    SYP -->|"activates"| Inflammation
    Aging{"Aging"}
    SYP -->|"activates"| Aging
    Ms{"Ms"}
    SYP -->|"activates"| Ms
    SYNCRIP["SYNCRIP"]
    SYP -->|"interacts with"| SYNCRIP
    Neurogenesis(["Neurogenesis"])
    SYP -->|"interacts with"| Neurogenesis
    CHRNA7["CHRNA7"]
    SYP -->|"regulates"| CHRNA7
    SYT1["SYT1"]
    SYP -->|"regulates"| SYT1
    STAT3["STAT3"]
    SYP -->|"regulates"| STAT3
    HMOX1["HMOX1"]
    SYP -->|"regulates"| HMOX1
    TRPV1["TRPV1"]
    SYP -->|"regulates"| TRPV1
    P2RY2["P2RY2"]
    SYP -->|"regulates"| P2RY2
    FOXP3["FOXP3"]
    SYP -->|"regulates"| FOXP3
    SYNCRIP -->|"interacts with"| SYP
    PANX1["PANX1"]
    PANX1 -->|"regulates"| SYP
    S100B["S100B"]
    S100B -->|"regulates"| SYP
    RELB["RELB"]
    RELB -->|"regulates"| SYP
    P2RY1["P2RY1"]
    P2RY1 -->|"regulates"| SYP
    CASP3["CASP3"]
    CASP3 -->|"regulates"| SYP
    SOCS3["SOCS3"]
    SOCS3 -->|"regulates"| SYP
    TRPA1["TRPA1"]
    TRPA1 -->|"regulates"| SYP
    GENES["GENES"]
    GENES -->|"regulates"| SYP
    CXCL2["CXCL2"]
    CXCL2 -->|"regulates"| SYP
    SNAP25["SNAP25"]
    SNAP25 -->|"regulates"| SYP
    P2RX7["P2RX7"]
    P2RX7 -->|"regulates"| SYP
    style SYP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (235)

TargetRelationTypeStr
Spinal cordexpressed_instructure0.90
Striatumexpressed_instructure0.90
Synaptic plasticitycomponent_ofprocess0.90
Reinnervationbiomarker_forprocess0.88
Motor functionassociated_withphenotype0.88

Incoming (217)

SourceRelationTypeStr
SV2Acorrelates_withprotein0.95
SV2Aco_expressed_withprotein0.90
NCSEdownregulatesdisease0.90
Oxytocinupregulatesdrug0.90
AdipoRonupregulatesdrug0.88

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found