Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SYP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SYP is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, expressed in. Associated with Aging, Als, Epilepsy. Connected to 68 entities in the SciDEX knowledge graph.
| Gene Symbol | SYP |
| Full Name | Synaptophysin |
| Chromosome | Xp11.23 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 38 kDa |
| Amino Acids | 313 aa |
| Exons | 4 |
| Pathways | Oxidative Stress |
| UniProt ID | [P08247](https://www.uniprot.org/uniprot/P08247) |
| Ensembl ID | ENSG00000157193 |
| OMIM | 313475 |
| GeneCards | SYP |
| Human Protein Atlas | SYP |
| Associated Diseases | Alzheimer, Motor function, Motor function recovery, neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | SYNCRIP, SNAP25, MTOR, P38, GFAP, TNF |
| KG Connections | 444 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SYP["<b>SYP</b>"]
Inflammation{"Inflammation"}
SYP -->|"activates"| Inflammation
Aging{"Aging"}
SYP -->|"activates"| Aging
Ms{"Ms"}
SYP -->|"activates"| Ms
SYNCRIP["SYNCRIP"]
SYP -->|"interacts with"| SYNCRIP
Neurogenesis(["Neurogenesis"])
SYP -->|"interacts with"| Neurogenesis
CHRNA7["CHRNA7"]
SYP -->|"regulates"| CHRNA7
SYT1["SYT1"]
SYP -->|"regulates"| SYT1
STAT3["STAT3"]
SYP -->|"regulates"| STAT3
HMOX1["HMOX1"]
SYP -->|"regulates"| HMOX1
TRPV1["TRPV1"]
SYP -->|"regulates"| TRPV1
P2RY2["P2RY2"]
SYP -->|"regulates"| P2RY2
FOXP3["FOXP3"]
SYP -->|"regulates"| FOXP3
SYNCRIP -->|"interacts with"| SYP
PANX1["PANX1"]
PANX1 -->|"regulates"| SYP
S100B["S100B"]
S100B -->|"regulates"| SYP
RELB["RELB"]
RELB -->|"regulates"| SYP
P2RY1["P2RY1"]
P2RY1 -->|"regulates"| SYP
CASP3["CASP3"]
CASP3 -->|"regulates"| SYP
SOCS3["SOCS3"]
SOCS3 -->|"regulates"| SYP
TRPA1["TRPA1"]
TRPA1 -->|"regulates"| SYP
GENES["GENES"]
GENES -->|"regulates"| SYP
CXCL2["CXCL2"]
CXCL2 -->|"regulates"| SYP
SNAP25["SNAP25"]
SNAP25 -->|"regulates"| SYP
P2RX7["P2RX7"]
P2RX7 -->|"regulates"| SYP
style SYP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Spinal cord | expressed_in | structure | 0.90 |
| Striatum | expressed_in | structure | 0.90 |
| Synaptic plasticity | component_of | process | 0.90 |
| Reinnervation | biomarker_for | process | 0.88 |
| Motor function | associated_with | phenotype | 0.88 |
| Synaptic Dysfunction | biomarker_for | mechanism | 0.85 |
| Motor function recovery | associated_with | phenotype | 0.85 |
| CDNF | co_expressed_with | protein | 0.85 |
| Neuropathic pain | protects_against | disease | 0.82 |
| Hippocampal injury | biomarker_for | process | 0.80 |
| Neuronal Damage | protects_against | process | 0.80 |
| Inflammation | activates | disease | 0.75 |
| oxidative stress response | participates_in | pathway | 0.70 |
| hippocampus | expressed_in | brain_region | 0.70 |
| autophagy | co_discussed | concept | 0.65 |
| tau | co_discussed | concept | 0.65 |
| Aging | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Epilepsy | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Neurodegeneration | expressed_in | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Pyroptosis | therapeutic_target | disease | 0.65 |
| Necroptosis | therapeutic_target | disease | 0.65 |
| Dementia | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| Dementia | expressed_in | disease | 0.65 |
| Alzheimer | expressed_in | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Depression | activates | disease | 0.65 |
| NEURON | causes | cell_type | 0.65 |
| mitochondria | co_discussed | concept | 0.65 |
| SYNCRIP | interacts_with | gene | 0.60 |
| CHRNA7 | regulates | gene | 0.60 |
| SYT1 | regulates | gene | 0.60 |
| STAT3 | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SV2A | correlates_with | protein | 0.95 |
| SV2A | co_expressed_with | protein | 0.90 |
| NCSE | downregulates | disease | 0.90 |
| Oxytocin | upregulates | drug | 0.90 |
| AdipoRon | upregulates | drug | 0.88 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.88 |
| Copper | inhibits | compound | 0.85 |
| Nerve implantation | upregulates | entity | 0.85 |
| Fisetin | upregulates | compound | 0.85 |
| Chlorogenic acid | upregulates | compound | 0.85 |
| Surgery | downregulates | process | 0.85 |
| Copper | downregulates | compound | 0.80 |
| BDNF | upregulates | gene | 0.80 |
| Transcranial near-infrared light | upregulates | compound | 0.80 |
| MECP2 | co_expressed_with | protein | 0.75 |
| REST | co_expressed_with | protein | 0.75 |
| MAPT | co_discussed | gene | 0.65 |
| SQSTM1 | co_discussed | gene | 0.65 |
| SYNCRIP | interacts_with | gene | 0.60 |
| PANX1 | regulates | gene | 0.60 |
| S100B | regulates | gene | 0.60 |
| RELB | regulates | gene | 0.60 |
| P2RY1 | regulates | gene | 0.60 |
| CASP3 | regulates | gene | 0.60 |
| SOCS3 | regulates | gene | 0.60 |
| TRPA1 | regulates | gene | 0.60 |
| CXCL2 | regulates | gene | 0.60 |
| SNAP25 | regulates | gene | 0.60 |
| P2RX7 | regulates | gene | 0.60 |
| SYT2 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| SOD2 | regulates | gene | 0.60 |
| NOS2 | regulates | gene | 0.60 |
| P2RX3 | regulates | gene | 0.60 |
| RELA | regulates | gene | 0.60 |
| SYNAPTOPHYSIN | associated_with | gene | 0.60 |
| PSD95 | activates | gene | 0.60 |
| ERK1 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| SYNCRIP | regulates | entity | 0.60 |
| HSP70 | inhibits | gene | 0.60 |
| STONIN2 | interacts_with | gene | 0.60 |
| SLC17A7 | biomarker_for | gene | 0.60 |
| SLC17A6 | biomarker_for | gene | 0.60 |
| SLC12A5 | biomarker_for | gene | 0.60 |
| SYN2 | biomarker_for | gene | 0.60 |
| GAD1 | biomarker_for | gene | 0.60 |
| ICAM1 | expressed_in | gene | 0.60 |
| TDP-43 | expressed_in | gene | 0.60 |
| ADAM10 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||