gene

CNTNAP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNTNAP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

2Outgoing

3Incoming

0Experiments

0Debates

Summary

CNTNAP3 encodes a neurexin family cell adhesion molecule involved in neuronal connectivity, synapse organization, and brain development.

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🧬 Gene Info

Gene Symbol	CNTNAP3
Function	CNTNAP3 belongs to the CNTNAP (Contactin-Associated Protein) subfamily of neurexin-related molecules
Primary Expression	the brain, where it localizes to both presynaptic and postsynaptic compartments, suggesting roles in bidirectional synaptic communication[@rozemann201
Amino Acids	1395 aa
Pathways	Autophagy
Ensembl ID	ENSG00000178199
GeneCards	CNTNAP3
Human Protein Atlas	CNTNAP3
PDZ-binding motif	C-terminal sequence interacts with PSD-95 and other scaffolding proteins
N-glycosylation sites	Multiple sites for post-translational modification
Neurexins	May form heterodimeric complexes with neurexin family members
Calcium channels	Interaction with voltage-gated calcium channels
Synaptic vesicle proteins	Potential roles in neurotransmitter release
Neuroligins	Binding to postsynaptic neuroligins for trans-synaptic adhesion
PSD-95 family	Through PDZ-binding motif
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AUTOPHAGY
KG Connections	5 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CNTNAP3 Gene - Contactin Associated Protein 3

gene · 1887 words

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Pathway Diagram

graph TD
    CNTNAP3["CNTNAP3"]
    ATG16L1["ATG16L1"]
    CNTNAP3 -->|"expressed in"| ATG16L1
    Autophagy(["Autophagy"])
    CNTNAP3 -->|"activates"| Autophagy
    neurodegeneration["neurodegeneration"]
    CNTNAP3 -->|"implicated in"| neurodegeneration
    GENE_MUTATIONS["GENE MUTATIONS"]
    GENE_MUTATIONS -->|"associated with"| CNTNAP3
    NOD2["NOD2"]
    NOD2 -->|"associated with"| CNTNAP3
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| CNTNAP3
    style CNTNAP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (2)

Target	Relation	Type	Str
ATG16L1	expressed_in	gene	0.60
Autophagy	activates	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
NOD2	associated_with	gene	0.60
GENE MUTATIONS	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CNTNAP3 in their description or question text

No additional research found